APL Nameplate
  • Volume/Page
  • Keyword
  • DOI
  • Citation
  • Advanced
   
 
 
 

Flickr Twitter UniPHY Group iResearch App Facebook

Applied Physics Letters / Volume 97 / Issue 4 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 97, 043701 (2010); doi:10.1063/1.3467194 (3 pages)

Differential conductance as a promising approach for rapid DNA sequencing with nanopore-embedded electrodes

Yuhui He1, Lubing Shao1, Ralph H. Scheicher2, Anton Grigoriev2, Rajeev Ahuja2,3, Shibing Long1, Zhuoyu Ji1, Zhaoan Yu1, and Ming Liu1

1Laboratory of Nano-Fabrication and Novel Devices Integrated Technology, Institute of Microelectronics, Chinese Academy of Sciences, Beijing 100029, People's Republic of China
2Department of Physics and Astronomy, Condensed Matter Theory Group, Box 516, Uppsala University, SE-751 20 Uppsala, Sweden
3Department of Materials and Engineering, Applied Materials Physics, Royal Institute of Technology (KTH), SE-100 44 Stockholm, Sweden

View MapView Map

(Received 31 March 2010; accepted 16 April 2010; published online 26 July 2010)

We propose an approach for nanopore-based DNA sequencing using characteristic transverse differential conductance. Molecular dynamics and electron transport simulations show that the transverse differential conductance during the translocation of DNA through the nanopore is distinguishable enough for the detection of the base sequence and can withstand electrical noise caused by DNA structure fluctuation. Our findings demonstrate several advantages of the transverse conductance approach, which may lead to important applications in rapid genome sequencing.

© 2010 American Institute of Physics

RELATED DATABASES

To view database links for this article, you need to log in.

KEYWORDS and PACS

Keywords

bioelectric phenomena, biological techniques, DNA, electrodes, electrophoresis, genomics, molecular biophysics, molecular dynamics method, nanobiotechnology, nanoporous materials

PACS

ARTICLE DATA

Permalink
http://link.aip.org/link/doi/10.1063/1.3467194

PUBLICATION DATA

ISSN:

0003-6951 (print)  
1077-3118 (online)

Publisher:

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    M. Zwolak and M. Di Ventra, Rev. Mod. Phys. 80, 141 (2008).

    R. Zikic, et al., Phys. Rev. E 74, 011919 (2006).

    W. -H. Soe, et al., Phys. Rev. Lett. 102, 176102 (2009).


For access to citing articles, you need to log in.


Figures (4)

Access to article objects (figures, tables, multimedia) requires a subscription; log in to view available files.
(Access to supplementary files, where available, is free for this journal.)



Close

Google Calendar

ADVERTISEMENT

Your Recent History Recent History Help

Recently Viewed

  1. Differential conductance as a promising approach for rapid DNA sequencing with nanopore-embedded electrodes
Go to AIP Home
Copyright © American Institute of Physics
close