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Applied Physics Letters / Volume 100 / Issue 1 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 100, 013702 (2012); http://dx.doi.org/10.1063/1.3673551 (4 pages)

A thermodynamical model for stress-fiber organization in contractile cells

Louis Foucard and Franck J. Vernerey

Department of Civil, Environmental and Architectural Engineering, University of Colorado, Boulder, Colorado 80309-0428, USA

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(Received 4 September 2011; accepted 5 December 2011; published online 4 January 2012)

Cell mechanical adaptivity to external stimuli is vital to many of its biological functions. A critical question is therefore to understand the formation and organization of the stress fibers from which emerge the cell’s mechanical properties. By accounting for the mechanical aspects and the viscoelastic behavior of stress fibers, we here propose a thermodynamic model to predict the formation and orientation of stress fibers in contractile cells subjected to constant or cyclic stretch and different substrate stiffness. Our results demonstrate that the stress fibers viscoelastic behavior plays a crucial role in their formation and organization and shows good consistency with various experiments.

© 2012 American Institute of Physics

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KEYWORDS and PACS

Keywords

biomechanics, cellular biophysics, fibres, internal stresses, physiological models, viscoelasticity

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3673551

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

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$abstract.society.value is a Member of CrossRef American Institute of Physics

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