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Applied Physics Letters / Volume 100 / Issue 1 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 100, 013703 (2012); http://dx.doi.org/10.1063/1.3672035 (4 pages)

Interaction of lipid vesicle with silver nanoparticle-serum albumin protein corona

Ran Chen1, Poonam Choudhary1, Ryan N. Schurr1, Priyanka Bhattacharya1, Jared M. Brown2, and Pu Chun Ke1

1Laboratory of Single-Molecule Biophysics and Polymer Physics, COMSET, Clemson University, Clemson, South Carolina 29634, USA
2Department of Pharmacology and Toxicology, East Carolina University, Greenville, North Carolina 27834, USA

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(Received 16 November 2011; accepted 2 December 2011; published online 5 January 2012)

The physical interaction between a lipid vesicle and a silver nanoparticle (AgNP)-human serum albumin (HSA) protein “corona” has been examined. Specifically, the binding of AgNPs and HSA was analyzed by spectrophotometry, and the induced conformational changes of the HSA were inferred from circular dichroism spectroscopy. The fluidity of the vesicle, a model system for mimicking cell membrane, was found to increase with the increased exposure to AgNP-HSA corona, though less pronounced compared to that induced by AgNPs alone. This study offers additional information for understanding the role of physical forces in nanoparticle-cell interaction and has implications for nanomedicine and nanotoxicology.

© 2012 American Institute of Physics

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KEYWORDS and PACS

Keywords

biochemistry, biomembranes, cellular biophysics, circular dichroism, corona, molecular biophysics, nanomedicine, nanoparticles, proteins, silver, spectrophotometry, toxicology

PACS

  • 87.15.K-

    Molecular interactions; membrane-protein interactions

  • 87.17.-d

    Cell processes

  • 87.15.B-

    Structure of biomolecules

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3672035

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    R. Chen, G. Huang, and P. C. Ke, Appl. Phys. Lett. 97, 093706 (2010)APPLAB000097000009093706000001.


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