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Applied Physics Letters / Volume 100 / Issue 1 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 100, 013704 (2012); http://dx.doi.org/10.1063/1.3675457 (3 pages)

Magnetoacoustic imaging of magnetic iron oxide nanoparticles embedded in biological tissues with microsecond magnetic stimulation

Gang Hu and Bin He

Department of Biomedical Engineering, University of Minnesota, Minnesota 55455, USA

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(Received 9 November 2011; accepted 13 December 2011; published online 6 January 2012)

We present an experimental study on magnetoacoustic imaging of superparamagnetic iron oxide (SPIO) nanoparticles embedded in biological tissues. In experiments, a large-current-carrying coil is used to deliver microsecond pulsed magnetic stimulation to samples. The ultrasound signals induced by magnetic forces on SPIO nanoparticles are measured by a rotating transducer. The distribution of nanoparticles is reconstructed by a back-projection imaging algorithm. The results demonstrated the feasibility to obtain cross-sectional image of magnetic nanoparticle targets with faithful dimensional and positional information, which suggests a promising tool for tomographic reconstruction of magnetic nanoparticle-labeled diseased tissues (e.g., cancerous tumor) in molecular or clinic imaging.

© 2012 American Institute of Physics

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KEYWORDS and PACS

Keywords

biomedical transducers, biomedical ultrasonics, cancer, coils, iron compounds, magnetic particles, magnetoacoustic effects, nanomedicine, nanoparticles, superparamagnetism, tumours, ultrasonic transducers

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3675457

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    R. Xia, X. Li, and B. He, Appl. Phys. Lett. 91, 083903 (2007)APPLAB000091000008083903000001.

    G. Hu, X. Li, and B. He, Appl. Phys. Lett. 97, 103705 (2010)APPLAB000097000010103705000001.

    G. Hu, E. Cressman, and B. He, Appl. Phys. Lett. 98, 023703 (2011)APPLAB000098000002023703000001.

    Y. Xu and L. H. V. Wang, Phys. Rev. Lett. 92, 033902 (2004).


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