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12 Mar 2012

Volume 100, Issue 11, Articles (11xxxx)

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Appl. Phys. Lett. 100, 111101 (2012); http://dx.doi.org/10.1063/1.3691957 (3 pages)

Christina Alpmann, Michael Esseling, Patrick Rose, and Cornelia Denz
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Eumelanin kinetics and sheet structure

J. U. Sutter, T. Bidláková, J. Karolin, and D. J. S. Birch

Appl. Phys. Lett. 100, 113701 (2012); http://dx.doi.org/10.1063/1.3694762 (4 pages) | Cited 1 time

Online Publication Date: 15 March 2012

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Melanins are common pigments with a non-repeating primary structure that is generally accepted to be composed of dihydroxyindoles. However, despite intensive research the secondary structure defining the minimum functional unit (protomolecule) remains elusive. We have revisited eumelanin formation in-situ during the non-enzymatic auto-oxidation of 3,4-dihydroxy-L-phenylalanine by using the fluorescence of thioflavin T; an extrinsic probe known to report on sheet structure. This approach obviates the complex intrinsic fluorescence and reveals a sigmoidal temporal dependence of assembly that is consistent with protomolecule formation and assembly into a stacked sheet structure rather than a randomized heteropolymer formed by monomer addition.
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87.15.bd Secondary structure
87.15.R- Reactions and kinetics
87.15.mq Luminescence

Selective killing of ovarian cancer cells through induction of apoptosis by nonequilibrium atmospheric pressure plasma

Sachiko Iseki, Kae Nakamura, Moemi Hayashi, Hiromasa Tanaka, Hiroki Kondo, Hiroaki Kajiyama, Hiroyuki Kano, Fumitaka Kikkawa, and Masaru Hori

Appl. Phys. Lett. 100, 113702 (2012); http://dx.doi.org/10.1063/1.3694928 (4 pages) | Cited 2 times

Online Publication Date: 15 March 2012

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Two independent ovarian cancer cell lines and fibroblast controls were treated with nonequilibrium atmospheric pressure plasma (NEAPP). Most ovarian cancer cells were detached from the culture dish by continuous plasma treatment to a single spot on the dish. Next, the plasma source was applied over the whole dish using a robot arm. In vitro cell proliferation assays showed that plasma treatments significantly decreased proliferation rates of ovarian cancer cells compared to fibroblast cells. Flow cytometry and western blot analysis showed that plasma treatment of ovarian cancer cells induced apoptosis. NEAPP could be a promising tool for therapy for ovarian cancers.
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87.85.-d Biomedical engineering
87.17.-d Cell processes
52.77.-j Plasma applications
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