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16 Apr 2012

Volume 100, Issue 16, Articles (16xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 100, 164101 (2012); http://dx.doi.org/10.1063/1.3702579 (4 pages)

Cheol-Ho Yun, Leslie Y. Yeo, James R. Friend, and Bernard Yan
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An electrostatic micromechanical biosensor for electrical detection of label-free DNA

Ji-Min Choi, Sung-Up Hwang, Chang-Hoon Kim, Hyun-Ho Yang, Cheulhee Jung, Hyun Gyu Park, Jun-Bo Yoon, and Yang-Kyu Choi

Appl. Phys. Lett. 100, 163701 (2012); http://dx.doi.org/10.1063/1.3703764 (5 pages)

Online Publication Date: 16 April 2012

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An electrostatic micromechanical biosensor is demonstrated for the label-free electrical detection of DNA, based on electrostatic actuation of a double-clamped micromechanical cantilever by driving gate electrodes to establish a current path through drain and source electrodes. Intrinsic charges in DNA alter surface charges on the gate by pre-charging concept and change the pull-in voltage (VPI), the voltage required to bring the suspended cantilever into contact with the drain electrode by induced electrostatic force. Its operation principle is verified by a numerical simulation and a capacitive model. The proposed biosensor represents a breakthrough for practical exploitation of electro-mechanical based sensors.
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87.80.-y Biophysical techniques (research methods)
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
87.14.gk DNA

Bringing aptamers into technologies: Impact of spacer terminations

M. Brut, A. Trapaidze, A. Estève, A. Bancaud, D. Estève, G. Landa, and M. Djafari-Rouhani

Appl. Phys. Lett. 100, 163702 (2012); http://dx.doi.org/10.1063/1.4704658 (3 pages)

Online Publication Date: 19 April 2012

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We propose a low cost modeling approach to screen the impact of aptamer structural modifications on their biomechanical stability. This responds to the current immature control of aptamer properties when integrated into bio-hybrid devices. We predict that common spacers (PEG, polythymine) disrupt aptamer rigidity, whereas alkyl chains have minimal incidence on its mechanical properties. We also observe that mutations in the active site are equally perturbative as PEG or polythymine. We suggest that the rational design of aptamer-based biosensing devices calls for a precise modeling of surface grafting and envision that our tool is readily adapted to face this challenge.
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87.15.-v Biomolecules: structure and physical properties
87.15.La Mechanical properties
87.80.-y Biophysical techniques (research methods)

Ferromagnetic nickel silicide nanowires for isolating primary CD4+ T lymphocytes

Dong-Joo Kim, Jin-Kyeong Seol, Mi-Ri Lee, Jung-Hwan Hyung, Gil-Sung Kim, Takeshi Ohgai, and Sang-Kwon Lee

Appl. Phys. Lett. 100, 163703 (2012); http://dx.doi.org/10.1063/1.4704924 (4 pages) | Cited 3 times

Online Publication Date: 20 April 2012

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Direct CD4+ T lymphocytes were separated from whole mouse splenocytes using 1-dimensional ferromagnetic nickel silicide nanowires (NiSi NWs). NiSi NWs were prepared by silver-assisted wet chemical etching of silicon and subsequent deposition and annealing of Ni. This method exhibits a separation efficiency of ∼93.5%, which is comparable to that of the state-of-the-art superparamagnetic bead-based cell capture (∼96.8%). Furthermore, this research shows potential for separation of other lymphocytes, B, natural killer and natural killer T cells, and even rare tumor cells simply by changing the biotin-conjugated antibodies.
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87.85.J- Biomaterials
75.50.Cc Other ferromagnetic metals and alloys
87.17.-d Cell processes
81.16.-c Methods of micro- and nanofabrication and processing
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