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23 Apr 2012

Volume 100, Issue 17, Articles (17xxxx)

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Appl. Phys. Lett. 100, 171903 (2012); http://dx.doi.org/10.1063/1.4704193 (3 pages)

Y. Peng and K. Kempa
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Precise and programmable manipulation of microbubbles by two-dimensional standing surface acoustic waves

Long Meng, Feiyan Cai, Juanjuan Chen, Lili Niu, Yanming Li, Junru Wu, and Hairong Zheng

Appl. Phys. Lett. 100, 173701 (2012); http://dx.doi.org/10.1063/1.4704922 (4 pages) | Cited 3 times

Online Publication Date: 23 April 2012

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A microfluidic device is developed to transport microbubbles (MBs) along a desired trajectory in fluid by introducing the phase-shift to a planar standing surface acoustic wave (SSAW). The radiation force of SSAW due to the acoustic pressure gradient modulated by a phase-shift can move MBs to anticipated potential wells in a programmable manner. The resolution of the transportation is approximately 2.2 µm and the estimated radiation force on the MBs is on the order of 10−9 N. This device can be used for manipulation of bioparticles, cell sorting, tissue engineering, and other biomedical applications.
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07.10.Cm Micromechanical devices and systems
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices

Deformation measurement of individual cells in large populations using a single-cell microchamber array chip

I. Doh, W. C. Lee, Y.-H. Cho, A. P. Pisano, and F. A. Kuypers

Appl. Phys. Lett. 100, 173702 (2012); http://dx.doi.org/10.1063/1.4704923 (3 pages) | Cited 1 time

Online Publication Date: 23 April 2012

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We analyze the deformability of individual red blood cells (RBCs) using SiCMA technology. Our approach is adequate to quickly measure large numbers of individual cells in heterogeneous populations. Individual cells are trapped in a large-scale array of micro-wells, and dielectrophoretic (DEP) force is applied to deform the cells. The simple structures of micro-wells and DEP electrodes facilitate the analysis of thousands of RBCs in parallel. This unique method allows the correlation of red cell deformation with cell surface and cytosolic characteristics to define the distribution of individual cellular characteristics in heterogeneous populations.
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87.17.Rt Cell adhesion and cell mechanics
87.80.Ek Mechanical and micromechanical techniques

A correction factor for ablation algorithms assuming deviations of Lambert-Beer’s law with a Gaussian-profile beam

Francisco Rodríguez-Marín, Rosario G. Anera, Aixa Alarcón, E. Hita, and J. R. Jiménez

Appl. Phys. Lett. 100, 173703 (2012); http://dx.doi.org/10.1063/1.4707389 (4 pages) | Cited 1 time

Online Publication Date: 26 April 2012

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In this work, we propose an adjustment factor to be considered in ablation algorithms used in refractive surgery. This adjustment factor takes into account potential deviations of Lambert-Beer’s law and the characteristics of a Gaussian-profile beam. To check whether the adjustment factor deduced is significant for visual function, we applied it to the paraxial Munnerlyn formula and found that it significantly influences the post-surgical corneal radius and p-factor. The use of the adjustment factor can help reduce the discrepancies in corneal shape between the real data and corneal shape expected when applying laser ablation algorithms.
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87.50.wp Therapeutic applications
87.50.wf Biophysical mechanisms of interaction
42.62.Be Biological and medical applications

Ca2+ waves across gaps in non-excitable cells induced by femtosecond laser exposure

Hao He, Shaoyang Wang, Xun Li, Shiyang Li, Minglie Hu, Youjia Cao, and Ching-Yue Wang

Appl. Phys. Lett. 100, 173704 (2012); http://dx.doi.org/10.1063/1.4707375 (4 pages)

Online Publication Date: 27 April 2012

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Calcium is a second messenger in all cells for various cellular processes. It was found in astrocytes and neurons that femtosecond laser stimulation could induce Ca2+ wave propagation. In this work, a femtosecond laser with a power above a certain threshold was focused on single HeLa/HEK293T cells for Ca2+ mobilization. Several types of Ca2+ oscillation patterns were found in neighboring cells. The Ca2+ wave propagated very fast across 40-μm gaps in the Ca2+-free medium mediated by the adenosine-triphosphate released from cells. This approach could provide a clean methodology to investigate the Ca2+ dynamics in non-excitable cells.
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87.50.W- Optical/infrared radiation effects
87.16.Vy Ion channels
87.18.Gh Cell-cell communication; collective behavior of motile cells
87.18.Mp Signal transduction networks
87.16.dp Transport, including channels, pores, and lateral diffusion
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