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2 Jan 2012

Volume 100, Issue 1, Articles (01xxxx)

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Appl. Phys. Lett. 100, 013101 (2012); http://dx.doi.org/10.1063/1.3673334 (3 pages)

Patrice Genevet, Nanfang Yu, Francesco Aieta, Jiao Lin, Mikhail A. Kats, Romain Blanchard, Marlan O. Scully, Zeno Gaburro, and Federico Capasso
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The infrared fingerprint signals of silica nanoparticles and its application in immunoassay

Yadan Ding, Xueying Chu, Xia Hong, Peng Zou, and Yichun Liu

Appl. Phys. Lett. 100, 013701 (2012); http://dx.doi.org/10.1063/1.3673549 (3 pages)

Online Publication Date: 3 January 2012

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Infrared absorption properties of silica nanoparticles were studied. The transverse optical and the longitudinal optical phonon modes from the silica were proved to be the characteristic spectroscopic fingerprint signals. Based on this, a sandwich-structured immunoassay was performed, and the detection of the analyte (human IgG) was achieved by using biofunctional silica nanoparticles as infrared probes. The immunoassay based on Fourier transform infrared reflection absorption spectroscopy of silica nanoparticles shows significant value for potential applications in many areas, such as biomedicine, food safety, and waste treatment.
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87.85.J- Biomaterials
87.85.Rs Nanotechnologies-applications

A thermodynamical model for stress-fiber organization in contractile cells

Louis Foucard and Franck J. Vernerey

Appl. Phys. Lett. 100, 013702 (2012); http://dx.doi.org/10.1063/1.3673551 (4 pages) | Cited 2 times

Online Publication Date: 4 January 2012

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Cell mechanical adaptivity to external stimuli is vital to many of its biological functions. A critical question is therefore to understand the formation and organization of the stress fibers from which emerge the cell’s mechanical properties. By accounting for the mechanical aspects and the viscoelastic behavior of stress fibers, we here propose a thermodynamic model to predict the formation and orientation of stress fibers in contractile cells subjected to constant or cyclic stretch and different substrate stiffness. Our results demonstrate that the stress fibers viscoelastic behavior plays a crucial role in their formation and organization and shows good consistency with various experiments.
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87.17.-d Cell processes
87.17.Rt Cell adhesion and cell mechanics

Interaction of lipid vesicle with silver nanoparticle-serum albumin protein corona

Ran Chen, Poonam Choudhary, Ryan N. Schurr, Priyanka Bhattacharya, Jared M. Brown, and Pu Chun Ke

Appl. Phys. Lett. 100, 013703 (2012); http://dx.doi.org/10.1063/1.3672035 (4 pages) | Cited 6 times

Online Publication Date: 5 January 2012

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The physical interaction between a lipid vesicle and a silver nanoparticle (AgNP)-human serum albumin (HSA) protein “corona” has been examined. Specifically, the binding of AgNPs and HSA was analyzed by spectrophotometry, and the induced conformational changes of the HSA were inferred from circular dichroism spectroscopy. The fluidity of the vesicle, a model system for mimicking cell membrane, was found to increase with the increased exposure to AgNP-HSA corona, though less pronounced compared to that induced by AgNPs alone. This study offers additional information for understanding the role of physical forces in nanoparticle-cell interaction and has implications for nanomedicine and nanotoxicology.
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87.15.K- Molecular interactions; membrane-protein interactions
87.17.-d Cell processes
87.15.B- Structure of biomolecules

Magnetoacoustic imaging of magnetic iron oxide nanoparticles embedded in biological tissues with microsecond magnetic stimulation

Gang Hu and Bin He

Appl. Phys. Lett. 100, 013704 (2012); http://dx.doi.org/10.1063/1.3675457 (3 pages) | Cited 1 time

Online Publication Date: 6 January 2012

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We present an experimental study on magnetoacoustic imaging of superparamagnetic iron oxide (SPIO) nanoparticles embedded in biological tissues. In experiments, a large-current-carrying coil is used to deliver microsecond pulsed magnetic stimulation to samples. The ultrasound signals induced by magnetic forces on SPIO nanoparticles are measured by a rotating transducer. The distribution of nanoparticles is reconstructed by a back-projection imaging algorithm. The results demonstrated the feasibility to obtain cross-sectional image of magnetic nanoparticle targets with faithful dimensional and positional information, which suggests a promising tool for tomographic reconstruction of magnetic nanoparticle-labeled diseased tissues (e.g., cancerous tumor) in molecular or clinic imaging.
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87.85.Rs Nanotechnologies-applications
87.63.dh Ultrasonographic imaging
87.19.xj Cancer
75.50.Tt Fine-particle systems; nanocrystalline materials
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