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Applied Physics Letters / Volume 100 / Issue 2 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 100, 023701 (2012); http://dx.doi.org/10.1063/1.3673335 (3 pages)

Double-functionalized nanopore-embedded gold electrodes for rapid DNA sequencing

Biswarup Pathak1, Henrik Löfås1, Jariyanee Prasongkit1, Anton Grigoriev1, Rajeev Ahuja1,2, and Ralph H. Scheicher1

1Division of Materials Theory, Department of Physics and Astronomy, Box 516, Uppsala University, SE-751 20 Uppsala, Sweden
2Applied Material Physics, Department of Materials Science and Engineering, Royal Institute of Technology (KTH), SE-100 44 Stockholm, Sweden

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(Received 16 September 2011; accepted 7 November 2011; published online 9 January 2012)

We have studied the effect of double-functionalization on gold electrodes for improving nanopore-based DNA sequencing. The functionalizing molecular probes are, respectively, capable of temporarily forming hydrogen bonds with both the nucleobase part and the phosphate group of the target DNA, thus potentially minimizing the structural fluctuations of a single-stranded DNA molecule passing between the gold electrodes. The results of our first-principles study indicate that the proposed setup yields current signals that differ by at least 1 order of magnitude for the four different nucleic acid bases, thus offering the possibility to electrically distinguish them.

© 2012 American Institute of Physics

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KEYWORDS and PACS

Keywords

ab initio calculations, biochemistry, DNA, electrodes, fluctuations, gold, hydrogen bonds, molecular biophysics, nanobiotechnology, nanostructured materials

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3673335

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

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