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Applied Physics Letters / Volume 100 / Issue 2 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 100, 023703 (2012); http://dx.doi.org/10.1063/1.3676271 (4 pages)

Label-free multiphoton imaging and photoablation of preinvasive cancer cells

Shuangmu Zhuo1, Jianxin Chen1, Guizhu Wu2, Xiaoqin Zhu1, Xingshan Jiang1, and Shusen Xie1

1Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou 350007, China
2First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China

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(Received 7 September 2011; accepted 21 December 2011; published online 10 January 2012)

Detection and treatment of early lesions in epithelial tissue offer several possibilities for curing cancer, but it is challenging. Here, we present an optical technique, the combination of multiphoton imaging and absorption, to label-freely detect and ablate preinvasive cancer cells in epithelial tissue. We find that multiphoton imaging can label-freely visualize the principal features of nuclear atypia associated with epithelial precancerous lesions, and the spatial localization of multiphoton absorption can perform targeted ablation of preinvasive cancer cells with micrometer-sized volume precision. These results indicate that this optical technique has the capability to label-freely visualize and remove preinvasive cancer cells in epithelial tissue. This study highlights the potential of this technique as a “seek-and-treat” tool for early lesions in epithelial tissue.

© 2012 American Institute of Physics

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KEYWORDS and PACS

Keywords

biomedical optical imaging, bio-optics, cancer, cellular effects of radiation

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3676271

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    T. L. Sun, Y. Liu, M. C. Sung, H. C. Chen, C. H. Yang, V. Hovhannisyan, W. C. Lin, W. L. Chen, L. L. Chiou, G. T. Huang et al., Appl. Phys. Lett. 95, 193703 (2009)APPLAB000095000019193703000001.

    C. C. Wang, F. C. Li, W. C. Lin, Y. F. Chen, S. J. Chen, S. J. Lin, and C. Y. Dong, Appl. Phys. Lett. 97, 113702 (2010)APPLAB000097000011113702000001.

    S. M. Zhuo, L. Q. Zheng, J. X. Chen, S. S. Xie, X. Q. Zhu, and X. S. Jiang, Appl. Phys. Lett. 97, 173701 (2010)APPLAB000097000017173701000001.

    M. S. Hutson and X. Y. Ma, Phys. Rev. Lett. 99, 158104 (2007).


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