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Applied Physics Letters / Volume 100 / Issue 2 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 100, 023704 (2012); http://dx.doi.org/10.1063/1.3676664 (3 pages)

Biomolecule detection based on Si single-electron transistors for highly sensitive integrated sensors on a single chip

Takashi Kudo and Anri Nakajima

Research Institute for Nanodevice and Bio Systems, Hiroshima University, 1-4-2 Kagamiyama, Higashihiroshima 739-8527, Japan

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(Received 12 October 2011; accepted 22 December 2011; published online 12 January 2012)

Biomolecule detection was achieved using a Si single-electron transistor (SET) for highly-sensitive detection. A multiple-island channel-structure was used for the SET to enable room-temperature operation and to increase sensitivity. Coulomb oscillation shifted against the gate voltage due to biotin-streptavidin binding. Coulomb oscillation has a possibility to increase transconductance (gm), and a higher gm leads to greater sensitivity to a charged target. Since a Si structure is important for integrating label-free-biomolecule and/or ion sensors into large-scale-integrated circuits, a Si SET with multiple islands should enable the integration of a sensor system on a single chip for multiplexed detections and simultaneous diagnoses.

© 2012 American Institute of Physics

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KEYWORDS, PACS, and IPC

Keywords

biosensors, elemental semiconductors, silicon, single electron transistors

PACS

International Patent Classification (IPC)

  • H01L29/00

    Semiconductor devices specially adapted for rectifying, amplifying, oscillating or switching and having at least one potential-jump barrier or surface barrier; Capacitors or resistors with at least one potential-jump barrier or surface barrier, e.g. pn-junction depletion layer or carrier concentration layer; Details of semiconductor bodies or of electrodes thereof

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3676664

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    T. Kudo and A. Nakajima, Appl. Phys. Lett. 98, 123705 (2011)APPLAB000098000012123705000001.

    A. Nakajima, Y. Ito, and S. Yokoyama, Appl. Phys. Lett. 81, 733 (2002)APPLAB000081000004000733000001.

    K. Ohkura, T. Kitade and A. Nakajima, J. Appl. Phys. 98, 124503 (2005)JAPIAU000098000012124503000001.

    T. Kitade, K. Ohkura, and A. Nakajima, Appl. Phys. Lett. 86, 123118 (2005)APPLAB000086000012123118000001.


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