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21 May 2012

Volume 100, Issue 21, Articles (21xxxx)

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Appl. Phys. Lett. 100, 213701 (2012); http://dx.doi.org/10.1063/1.3701135 (4 pages)

Wen Lo, Ara Ghazaryan, Chien-Hsin Tso, Po-Sheng Hu, Wei-Liang Chen, Tsung-Rong Kuo, Sung-Jan Lin, Shean-Jen Chen, Chia-Chun Chen, and Chen-Yuan Dong
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Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

Wen Lo, Ara Ghazaryan, Chien-Hsin Tso, Po-Sheng Hu, Wei-Liang Chen, Tsung-Rong Kuo, Sung-Jan Lin, Shean-Jen Chen, Chia-Chun Chen, and Chen-Yuan Dong

Appl. Phys. Lett. 100, 213701 (2012); http://dx.doi.org/10.1063/1.3701135 (4 pages)

Online Publication Date: 21 May 2012

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Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.
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87.16.dp Transport, including channels, pores, and lateral diffusion

A photonic crystal cavity-optical fiber tip nanoparticle sensor for biomedical applications

Gary Shambat, Sri Rajasekhar Kothapalli, Aman Khurana, J. Provine, Tomas Sarmiento, Kai Cheng, Zhen Cheng, James Harris, Heike Daldrup-Link, Sanjiv Sam Gambhir, and Jelena Vučković

Appl. Phys. Lett. 100, 213702 (2012); http://dx.doi.org/10.1063/1.4719520 (4 pages)

Online Publication Date: 22 May 2012

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We present a sensor capable of detecting solution-based nanoparticles using an optical fiber tip functionalized with a photonic crystal cavity. When sensor tips are retracted from a nanoparticle solution after being submerged, we find that a combination of convective fluid forces and optically induced trapping cause an aggregation of nanoparticles to form directly on cavity surfaces. A simple readout of quantum dot photoluminescence coupled to the optical fiber shows that nanoparticle presence and concentration can be detected through modified cavity properties. Our sensor can detect both gold and iron oxide nanoparticles and can be utilized for molecular sensing applications in biomedicine.
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87.85.Rs Nanotechnologies-applications
87.19.xj Cancer
87.85.Pq Biomedical imaging

Accumulation mode field-effect transistors for improved sensitivity in nanowire-based biosensors

David J. Baek, Juan P. Duarte, Dong-Il Moon, Chang-Hoon Kim, Jae-Hyuk Ahn, and Yang-Kyu Choi

Appl. Phys. Lett. 100, 213703 (2012); http://dx.doi.org/10.1063/1.4723843 (4 pages)

Online Publication Date: 25 May 2012

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In this work, nanowire field-effect transistors (NW-FETs) constructed from a top-down approach has been utilized for the detection of biomolecules. Here, we demonstrate that the sensitivity of NW-FET sensors can be greatly enhanced when the same dopant type is used for both channel region and source and drain. This type of FET, known as accumulation mode field-effect transistors (AM-FETs), functions under different operating principle compared with conventional inversion mode FETs. The improved sensitivity is attributed to the different conduction mechanism and current components of AM devices. The results have been verified through a direct comparison with a conventional FET.
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87.80.-y Biophysical techniques (research methods)
82.80.-d Chemical analysis and related physical methods of analysis
85.30.Tv Field effect devices
85.35.Be Quantum well devices (quantum dots, quantum wires, etc.)
81.07.Gf Nanowires
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