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16 Jan 2012

Volume 100, Issue 3, Articles (03xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 100, 033109 (2012); http://dx.doi.org/10.1063/1.3664636 (3 pages)

Sang H. Yun, Hyung-Seok Lee, Young Ha Kwon, Mats Göthelid, Sang Mo Koo, Lars Wågberg, Ulf O. Karlsson, and Jan Linnros
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Microwave-induced thermoacoustic computed tomography with a clinical contrast agent of NMG2[Gd(DTPA)]

Huan Qin, Sihua Yang, and Da Xing

Appl. Phys. Lett. 100, 033701 (2012); http://dx.doi.org/10.1063/1.3678022 (3 pages)

Online Publication Date: 18 January 2012

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NMG2[Gd(DTPA)], a clinical contrast agent, was investigated for microwave-induced thermoacoustic computed tomography (CT). Due to ionic conduction and magnetic dipole rotation in the presence of microwave field, microwave energy absorbed by NMG2[Gd(DTPA)] would be transformed to thermoacoustic signals based on the thermoelastic effect. The experimental results demonstrated that NMG2[Gd(DTPA)] at a concentration of 10 mM provided effective enhancement compared with water. The enhancement of NMG2[Gd(DTPA)] for thermoacoustic CT was further demonstrated in invivo tumor-bearing mouse. The theory and experimental results indicate that the clinically available NMG2[Gd(DTPA)] will promote the medical applications of thermoacoustic CT.
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87.57.Q- Computed tomography
87.63.D- Ultrasonography
87.19.Pp Biothermics and thermal processes in biology
87.19.xj Cancer
87.57.cj Contrast

Centering of organic-inorganic hybrid liposomal cerasomes in electrospun gelatin nanofibers

Zhengbao Zha, Siu Ling Leung, Zhifei Dai, and Xiaoyi Wu

Appl. Phys. Lett. 100, 033702 (2012); http://dx.doi.org/10.1063/1.3678040 (3 pages) | Cited 1 time

Online Publication Date: 18 January 2012

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A study investigating the embedding of stabilized organic-inorganic liposomal cerasomes in gelatin nanofibers through the electrospinning of cerasome-dispersed gelatin aqueous solution is presented. Fluorescent and transmission electron microscopy confirm the embedding and centering of cerasomes in the electrospun nanofibers. A simple mechanism is proposed for the centering of cerasomes in gelatin nanofibers. The ability to incorporate cerasomes capable of encapsulating a variety of bioactive molecules provides a promising method to functionalize polymer nanofibers.
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87.80.-y Biophysical techniques (research methods)
87.16.D- Membranes, bilayers, and vesicles
81.07.Pr Organic-inorganic hybrid nanostructures
82.70.Gg Gels and sols
87.14.Cc Lipids
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