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23 Jan 2012

Volume 100, Issue 4, Articles (04xxxx)

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Appl. Phys. Lett. 100, 041101 (2012); http://dx.doi.org/10.1063/1.3675885 (4 pages)

Seung Ho Choi and Young L. Kim
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Optical planar waveguide for cell counting

John LeBlanc, Andrew J. Mueller, Adrian Prinz, and Manish J. Butte

Appl. Phys. Lett. 100, 043701 (2012); http://dx.doi.org/10.1063/1.3678339 (5 pages) | Cited 1 time

Online Publication Date: 23 January 2012

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Low cost counting of cells has medical applications in screening, military medicine, disaster medicine, and rural healthcare. In this report, we present a shallow, buried, planar waveguide fabricated by potassium ion exchange in glass that enables low-cost and rapid counting of metal-tagged objects that lie in the evanescent field of the waveguide. Laser light transmitted through the waveguide was attenuated proportionately to the presence of metal-coated microstructures fabricated from photoresist. This technology enables the low-cost enumeration of cells from blood, urine, or other biofluids.
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87.85.-d Biomedical engineering
42.79.Gn Optical waveguides and couplers

Evidence of ferroelectricity and phase transition in pressed diphenylalanine peptide nanotubes

Igor Bdikin, Vladimir Bystrov, Svitlana Kopyl, Rui P. G. Lopes, Ivonne Delgadillo, José Gracio, Elena Mishina, Alexander Sigov, and Andrei L. Kholkin

Appl. Phys. Lett. 100, 043702 (2012); http://dx.doi.org/10.1063/1.3676417 (4 pages) | Cited 8 times

Online Publication Date: 24 January 2012

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Self-assembled peptide nanotubes (PNT) are unique nanoscale objects having a great potential for a multitude of applications. Strong piezoactivity and polar properties in aromatic dipeptides were recently observed in stand-alone nanotubes using piezoresponse force microscopy and 2nd harmonic generation. In this work, we report macroscopic dielectric and polarization vs. field measurements on pressed PNTs before and after annealing at 150 °C. The results corroborate nanoscale study and present a clear evidence of ferroelectric-like behaviour and phase transition in this technologically important material. The dielectric constant of PNT pellets obeys apparent Curie-Weiss (CW) law with the CW constant C ≈ 230 °C and transition temperature at T ≈ 142 °C.
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77.80.B- Phase transitions and Curie point
77.22.Ch Permittivity (dielectric function)
77.22.Ej Polarization and depolarization
81.16.Dn Self-assembly
81.40.Gh Other heat and thermomechanical treatments

Intravascular ultrasound chirp imaging

D. Maresca, K. Jansen, G. Renaud, G. van Soest, X. Li, Q. Zhou, N. de Jong, K. K. Shung, and A. F. W. van der Steen

Appl. Phys. Lett. 100, 043703 (2012); http://dx.doi.org/10.1063/1.3679375 (3 pages) | Cited 2 times

Online Publication Date: 25 January 2012

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We demonstrate the feasibility of intravascular ultrasound (IVUS) chirp imaging as well as chirp reversal ultrasound contrast imaging at intravascular ultrasound frequency. Chirp excitations were emitted with a 34 MHz single crystal intravascular transducer and compared to conventional Gaussian-shaped pulses of equal acoustic pressure. The signal to noise ratio of the chirp images was increased by up to 9 dB relative to the conventional images. Imaging of contrast microbubbles was implemented by chirp reversal, achieving a contrast to tissue ratio of 12 dB. The method shows potential for intravascular imaging of structures in and beyond coronary atherosclerotic plaques including vasa vasorum.
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87.63.dh Ultrasonographic imaging
87.85.Ox Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)
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