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Applied Physics Letters / Volume 100 / Issue 5 / BIOPHYSICS AND BIO-INSPIRED SYSTEMS

Appl. Phys. Lett. 100, 053701 (2012); http://dx.doi.org/10.1063/1.3681580 (4 pages)

ZnS-nanocrystals/polypyrrole nanocomposite film based immunosensor

Sujeet K. Mishra, Renu Pasricha, Ashok M Biradar, and Rajesh

National Physical Laboratory (Council of Scientific & Industrial Research), New Delhi 110012, India

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(Received 12 November 2011; accepted 12 January 2012; published online 1 February 2012)

We report an electrochemically synthesized ZnS nanocrystals modified polypyrrole (PPy) nanocomposite film based immunosensor for the detection of C-reactive protein (αCRP). The ZnS-PPy composite film was characterized by transmission electron microscopy (TEM), atomic force microscopy (AFM) and electrochemical techniques. The modified film showed good biocompatibility with efficient binding to protein antibody (αCRP-Ab) molecules through ZnS nanocrystals, exhibited an attractive platform for immunosensor fabrication. The electrical and sensing properties of the polymer composite film of different thickness towards protein antigen (αCRP-Ag) were delineated. The immunosensor exhibited an impedance response to αCRP-Ag concentration in a linear range from 10 ng to 10 μg mL−1.

© 2012 American Institute of Physics

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KEYWORDS, PACS, and IPC

Keywords

atomic force microscopy, biochemistry, bioelectric phenomena, biosensors, electrochemical analysis, molecular biophysics, nanobiotechnology, nanocomposites, nanofabrication, polymer films, proteins, transmission electron microscopy, zinc compounds

PACS

  • 87.85.Rs

    Nanotechnologies-applications

  • 81.07.-b

    Nanoscale materials and structures: fabrication and characterization

  • 82.35.Np

    Nanoparticles in polymers

  • 82.35.Pq

    Biopolymers, biopolymerization

  • 87.14.E-

    Proteins

International Patent Classification (IPC)

  • B82B1/00

    Nano-structures

  • B82B3/00

    Manufacture or treatment of nano-structures

  • C12

    Biochemistry; Beer; Spirits; Wine; Vinegar; Microbiology; Enzymology; Mutation or genetic engineering

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.3681580

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    Rajesh, Basanta K. Das, Sira Srinives, and Ashok Mulchandani, Appl. Phys. Lett. 98, 013701 (2011)APPLAB000098000001013701000001.

    A. Kaushik, P. R. Solanki, M. K. Pandey, S. Ahmad, and B. D. Malhotra, Appl. Phys. Lett. 95, 173703 (2009)APPLAB000095000017173703000001.

    Y. P. Timalsina, J. Branan, B. E. Aston, K. Noren, G. Corti, R. Schumacher, and D. N. Ncllroy, J. Appl. Phys. 110, 014901 (2011)JAPIAU000110000001014901000001.

    Rajesh, T. Sarkar, and A. Mulchandani, Appl. Phys. Lett. 99, 173110 (2011)APPLAB000099000017173110000001.

    A. Joshi, D. K. Aswal, S. K. Gupta, J. V. Yakhmi, and S. A. Gangal, Appl. Phys. Lett. 94, 103115 (2009)APPLAB000094000010103115000001.


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