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13 Feb 2012

Volume 100, Issue 7, Articles (07xxxx)

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Appl. Phys. Lett. 100, 073501 (2012); http://dx.doi.org/10.1063/1.3682479 (3 pages)

S. Tongay, M. Lemaitre, J. Fridmann, A. F. Hebard, B. P. Gila, and B. R. Appleton
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Fabrication of high-performance fully depleted silicon-on-insulator based dual-gate ion-sensitive field-effect transistor beyond the Nernstian limit

Hyun-June Jang and Won-Ju Cho

Appl. Phys. Lett. 100, 073701 (2012); http://dx.doi.org/10.1063/1.3685497 (4 pages) | Cited 3 times

Online Publication Date: 14 February 2012

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High-performance dual-gate (DG) ion-sensitive field-effect transistors (ISFETs) beyond the Nernstian limit of 59 mV/pH were realized using the fully depleted (FD) silicon-on-insulator (SOI) substrate. The FD SOI-based DG ISFET exhibited a significantly enhanced pH sensitivity of 379.2 mV/pH for DG operation amplified by capacitive coupling, while it exhibited a relatively poor sensitivity of 47.9 mV/pH for single-gate (SG) operation. Meanwhile, the non-ideal effects for long-term use slightly increased by the DG operation compared to the SG operation. Therefore, the FD SOI-based DG ISFETs compatible with the complementary metal-oxide-semiconductor process are considered to be very promising bio-chemical sensors.
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85.30.Tv Field effect devices

Temperature-modulated fluorescence tomography in a turbid media

Yuting Lin (林钰婷), Linden Bolisay, Michael Ghijsen, Tiffany C. Kwong, and Gultekin Gulsen

Appl. Phys. Lett. 100, 073702 (2012); http://dx.doi.org/10.1063/1.3681378 (4 pages) | Cited 4 times

Online Publication Date: 15 February 2012

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High scattering in biological tissues makes fluorescence tomography inverse problem very challenging in thick medium. We describe an approach termed “temperature-modulated fluorescence tomography” that can acquire fluorescence images at focused ultrasound resolution. By utilizing recently emerged temperature sensitive fluorescence contrast agents, this technique provides fluorescence images with high resolution prior to any reconstruction process. We demonstrate that this technique is well suited to resolve small fluorescence targets located several centimeters deep in tissue.
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87.63.L- Visual imaging
42.30.Wb Image reconstruction; tomography
43.80.Qf Medical diagnosis with acoustics
87.63.Hg Thermography
87.63.D- Ultrasonography

Transient state kinetic investigation of ferritin iron release

G. Ciasca, M. Papi, M. Chiarpotto, M. Rodio, G. Campi, C. Rossi, P. De Sole, and A. Bianconi

Appl. Phys. Lett. 100, 073703 (2012); http://dx.doi.org/10.1063/1.3685706 (3 pages) | Cited 3 times

Online Publication Date: 16 February 2012

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Increased iron concentration in tissues appears to be a factor in the genesis and development of inflammatory and degenerative diseases. By means of real-time small angle x-ray scattering measurements, we studied the kinetics of iron release from the ferritin inorganic core as a function of time and distance from the iron core centre. Accordingly, the iron release process follows a three step model: (i) a defect nucleation in the outer part of the mineral core, (ii) the diffusion of the reducing agent towards the inner part of the core, and (iii) the erosion of the core from the inner to the outer part.
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87.15.B- Structure of biomolecules
87.64.Bx Electron, neutron and x-ray diffraction and scattering
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