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24 Sep 2012

Volume 101, Issue 13, Articles (13xxxx)

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Appl. Phys. Lett. 101, 133101 (2012); http://dx.doi.org/10.1063/1.4752467 (5 pages)

Yen Husn Su and Wei-Yu Chen
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Cell-encapsulating droplet formation and freezing

Jae Ryoun Youn and Young Seok Song

Appl. Phys. Lett. 101, 133701 (2012); http://dx.doi.org/10.1063/1.4754611 (4 pages)

Online Publication Date: 24 September 2012

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Cell-encapsulating droplets are vitrified for biopreservation applications. The dynamics of micro-droplet formation and its freezing mechanism are analyzed numerically and experimentally. In addition, the microdroplet encapsulation technique is applied to cryopreserve cells.
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87.85.jc Electrical, thermal, and mechanical properties of biological matter
07.20.Mc Cryogenics; refrigerators, low-temperature detectors, and other low-temperature equipment
87.17.-d Cell processes

Formation and cell translocation of carbon nanotube-fibrinogen protein corona

Ran Chen, Slaven Radic, Poonam Choudhary, Kimberley G. Ledwell, George Huang, Jared M. Brown, and Pu Chun Ke

Appl. Phys. Lett. 101, 133702 (2012); http://dx.doi.org/10.1063/1.4756794 (4 pages)

Online Publication Date: 27 September 2012

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The binding of plasma fibrinogen with both single-walled and multi-walled carbon nanotubes (SWNTs and MWNTs) has been examined. Specifically, our absorbance study indicated that MWNTs were coated with multi-layers of fibrinogen to render a “hard protein corona,” while SWNTs were adsorbed with thin layers of the protein to precipitate out of the aqueous phase. In addition, static quenching as a result of energy transfer from fluorescently labeled fibrinogen to their nanotube substrates was revealed by Stern-Volmer analysis. When exposed to HT-29 cells, the nanotubes and fibrinogen could readily dissociate, possibly stemming from their differential affinities for the amphiphilic membrane bilayer.
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81.16.-c Methods of micro- and nanofabrication and processing
87.14.ep Membrane proteins
87.15.kt Protein-membrane interactions
87.15.M- Spectra of biomolecules
87.15.rs Dissociation
87.16.dr Assembly and interactions

Development of high-performance fully depleted silicon-on-insulator based extended-gate field-effect transistor using the parasitic bipolar junction transistor effect

Jin-Kwon Park and Won-Ju Cho

Appl. Phys. Lett. 101, 133703 (2012); http://dx.doi.org/10.1063/1.4757000 (3 pages)

Online Publication Date: 28 September 2012

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Latch based extended-gate field effect transistors (EGFETs) with a high on/off current ratio were realized on the fully depleted silicon-on-insulator (SOI) substrate. A large on/off current ratio characteristic as high as 104 with a very steep subthreshold swing close to 0 mV/dec was achieved by using the latch characteristic of the SOI substrate, which means it is highly sensitive to the small surface potential variation of biomaterials. Therefore, latch based EGFET sensors are a very promising candidate to break through the poor signal to the noise ratio exposed on conventional biosensors.
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85.30.Tv Field effect devices
85.30.Pq Bipolar transistors
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