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1 Oct 2012

Volume 101, Issue 14, Articles (14xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 101, 141101 (2012); http://dx.doi.org/10.1063/1.4742864 (4 pages)

Po-Hsun Huang, Michael Ian Lapsley, Daniel Ahmed, Yuchao Chen, Lin Wang, and Tony Jun Huang
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Neuronal alignment on asymmetric textured surfaces

Ross Beighley, Elise Spedden, Koray Sekeroglu, Timothy Atherton, Melik C. Demirel, and Cristian Staii

Appl. Phys. Lett. 101, 143701 (2012); http://dx.doi.org/10.1063/1.4755837 (5 pages) | Cited 1 time

Online Publication Date: 2 October 2012

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Show Abstract
Axonal growth and the formation of synaptic connections are key steps in the development of the nervous system. Here, we present experimental and theoretical results on axonal growth and interconnectivity in order to elucidate some of the basic rules that neuronal cells use for functional connections with one another. We demonstrate that a unidirectional nanotextured surface can bias axonal growth. We perform a systematic investigation of neuronal processes on asymmetric surfaces and quantify the role that biomechanical surface cues play in neuronal growth. These results represent an important step towards engineering directed axonal growth for neuro-regeneration studies.
Show PACS
87.85.Lf Tissue engineering
61.46.-w Structure of nanoscale materials
87.17.Ee Growth and division
87.18.Sn Neural networks and synaptic communication
68.35.B- Structure of clean surfaces (and surface reconstruction)
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