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5 Nov 2012

Volume 101, Issue 19, Articles (19xxxx)

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Appl. Phys. Lett. 101, 193101 (2012); http://dx.doi.org/10.1063/1.4764508 (4 pages)

Ryan T. Tucker, Allan L. Beaudry, Joshua M. LaForge, Michael T. Taschuk, and Michael J. Brett
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A biomimetic mechanism for antibody immobilization on lipid nanofibers for cell capture

Zhengbao Zha, Linan Jiang, Zhifei Dai, and Xiaoyi Wu

Appl. Phys. Lett. 101, 193701 (2012); http://dx.doi.org/10.1063/1.4766191 (4 pages)

Online Publication Date: 6 November 2012

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The immobilization of membrane-bound molecules on organic-inorganic cholesteryl-succinyl silane (CSS) nanofibers is investigated. Fluorescent microscopy and a cell capture assay confirm the stable and functional immobilization of membrane-bound antibodies and imaging agents on the electrospun CSS nanofibers. An insert-and-tighten mechanism is proposed for the observed hydration-induced reduction in lipid nanofiber diameter, the immobilization of membrane-bound molecules, and the improved efficiency of cell capture by the functionalized CSS nanofibers over their film counterparts. The ability to stably and functionally immobilize membrane-bound molecules on the CSS nanofibers presents a promising method to functionalize lipid-based nanomaterials.
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87.16.dp Transport, including channels, pores, and lateral diffusion
87.14.Cc Lipids
87.16.-b Subcellular structure and processes

Electrical properties of in vitro biomineralized recombinant silicatein deposited by microfluidics

Stefano Pagliara, Alessandro Polini, Andrea Camposeo, Heinz C. Schröder, Werner E. G. Müller, and Dario Pisignano

Appl. Phys. Lett. 101, 193702 (2012); http://dx.doi.org/10.1063/1.4766186 (4 pages) | Cited 1 time

Online Publication Date: 8 November 2012

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We report the fabrication of silica dielectrics obtained by in vitro biomineralization of recombinant silicatein. We exploit pressure-driven microfluidics to deposit silicatein which catalyses the deposition of silica features with thickness in the range 2–6 μm. We follow the biomineralization process with staining and confocal fluorescence for an incubation time up to 5 days and correspondingly characterize the leakage current through the resulting biomineralized silica layer by embedding it into a metal-insulator-metal device. We further characterize the morphology of the biosilica surface through atomic force and scanning electron microscopy and demonstrate the electrical insulation within planar electrodes patterned over such surface with leakage currents in the pA range for applied bias up to tens of V.
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87.85.J- Biomaterials
85.30.Tv Field effect devices
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
87.80.Ek Mechanical and micromechanical techniques
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