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9 Jul 2012

Volume 101, Issue 2, Articles (02xxxx)

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Appl. Phys. Lett. 101, 023101 (2012); http://dx.doi.org/10.1063/1.4731792 (4 pages)

Feng Wang, Ayan Chakrabarty, Fred Minkowski, Kai Sun, and Qi-Huo Wei
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Stability of electrically induced-polarization in poly (L-lactic) acid for bone regeneration

Nathalie Barroca, Paula M. Vilarinho, Maria Helena V. Fernandes, Pankaj Sharma, and Alexei Gruverman

Appl. Phys. Lett. 101, 023701 (2012); http://dx.doi.org/10.1063/1.4729619 (4 pages) | Cited 1 time

Online Publication Date: 10 July 2012

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This paper describes the decay kinetics of electrically induced polarization of poly(L-lactic) acid (PLLA) via piezoresponse force microscopy. Two crystalline forms of PLLA (α and α′) were electrically poled at different temperatures (room and above glass transition). Poling at temperatures above glass transition allowed obtaining polarization stable up to 10 days for both forms. This period is enough to trigger and maintain proteins adhesion and cells proliferation, if PLLA is used as a platform for tissue growth. When poled at room temperature, both structures lose polarization after a short time (minutes to hours) being polarization in α PLLA stable for longer time.
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87.85.jj Biocompatibility
87.17.-d Cell processes
87.14.E- Proteins

Lipid bilayer array for simultaneous recording of ion channel activities

Ayumi Hirano-Iwata, Tomohiro Nasu, Azusa Oshima, Yasuo Kimura, and Michio Niwano

Appl. Phys. Lett. 101, 023702 (2012); http://dx.doi.org/10.1063/1.4736263 (3 pages) | Cited 2 times

Online Publication Date: 12 July 2012

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This paper describes an array of stable and reduced-solvent bilayer lipid membranes (BLMs) formed in microfabricated silicon chips. BLMs were first vertically formed simultaneously and then turned 90° in order to realize a horizontal BLM array. Since the present BLMs are mechanically stable and robust, the BLMs survive this relatively tough process. Typically, a ∼60% yield in simultaneous BLM formation over 9 sites was obtained. Parallel recordings of gramicidin channel activities from different BLMs were demonstrated. The present system has great potential as a platform of BLM-based high throughput drug screening for ion channel proteins.
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87.16.dp Transport, including channels, pores, and lateral diffusion
87.16.Vy Ion channels
85.30.-z Semiconductor devices

Nanostructured nickel oxide film for application to fish freshness biosensor

Surendra K. Yadav, Jay Singh, Ved Varun Agrawal, and B. D. Malhotra

Appl. Phys. Lett. 101, 023703 (2012); http://dx.doi.org/10.1063/1.4736578 (4 pages) | Cited 1 time

Online Publication Date: 13 July 2012

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Xanthine oxidase (XOx) has been physisorbed onto nanostructured nickel oxide (n-NiO, ∼41 nm), electrophoretically deposited onto indium-tin-oxide (ITO) glass substrate using poly-ethylene glycol via co-precipitation. The electrochemical response studies of the XOx/n-NiO/ITO bioelectrode show linear response in the xanthine concentration range as 10–200 μM (R2 = 0.9989), sensitivity as 0.6214 μA/μM cm2, detection limit as 2.989 μM, standard deviation as 0.6192 μA, response time of 15 s with the stability of 100 days. The observed low value (0.0306 mM) Michaelis–Menten constant (Km) indicates high affinity of XOx towards xanthine.
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07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
07.10.Cm Micromechanical devices and systems
81.15.Pq Electrodeposition, electroplating
81.16.Be Chemical synthesis methods
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
87.14.ej Enzymes
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