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23 Jul 2012

Volume 101, Issue 4, Articles (04xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 101, 043101 (2012); http://dx.doi.org/10.1063/1.4737152 (4 pages)

Toshiaki Tanigaki, Yoshikatsu Inada, Shinji Aizawa, Takahiro Suzuki, Hyun Soon Park, Tsuyoshi Matsuda, Akira Taniyama, Daisuke Shindo, and Akira Tonomura
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Viable capture and release of cancer cells in human whole blood

Il Doh, Hwan-il Yoo, Young-Ho Cho, Jinseon Lee, Hong Kwan Kim, and Jhingook Kim

Appl. Phys. Lett. 101, 043701 (2012); http://dx.doi.org/10.1063/1.4737936 (4 pages) | Cited 1 time

Online Publication Date: 23 July 2012

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We present viable cancer cell isolation devices utilizing the physical properties of cells. The tapered slit structure is proposed to isolate cancer cells from blood cells and collect them by reversed flow. From the experimental study using the spiked cancer cells in human whole blood, we verified the capability of the present cancer cell isolation chip in terms of capture efficiency, viability, and release rate. The viable cancer cells obtained from the present chip can be used for the further applications of cancer diagnosis, treatment monitoring, and new target drug development for cancer stem cells.
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87.85.Ox Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS)
47.85.Np Fluidics
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
87.17.Uv Biotechnology of cell processes
87.19.xj Cancer
87.85.gf Fluid mechanics and rheology

Microwave-acoustic phasoscopy for tissue characterization

Fei Gao, Yuanjin Zheng, and Dongfang Wang

Appl. Phys. Lett. 101, 043702 (2012); http://dx.doi.org/10.1063/1.4739493 (5 pages) | Cited 1 time

Online Publication Date: 25 July 2012

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In this letter, we present a method named microwave-acoustic phasoscopy (MAPC) by collecting both scattered microwave energy and microwave-induced thermoacoustic wave energy for tissue characterization. Different from conventional amplitude and spectrum analysis, we propose to evaluate the microwave-acoustic phase for tissue characterization. Theoretical analysis and experiment verification are performed to show a good agreement. Four different biological tissues are well differentiated in phase region using the proposed MAPC. This attempt of exploring intrinsic relationship between scattered microwave and induced thermoacoustic signals simultaneously provides phase contrast for tissue characterization, showing significant potential in developing phase-contrast imaging prototype based on MAPC theory.
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43.80.Sh Medical use of ultrasonics for tissue modification (permanent and temporary)
87.17.-d Cell processes

Mapping the surface charge distribution of amyloid fibril

Gyudo Lee, Wonseok Lee, Hyungbeen Lee, Sang Woo Lee, Dae Sung Yoon, Kilho Eom, and Taeyun Kwon

Appl. Phys. Lett. 101, 043703 (2012); http://dx.doi.org/10.1063/1.4739494 (4 pages) | Cited 1 time

Online Publication Date: 26 July 2012

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It is of high importance to measure and map the surface charge distribution of amyloids, since electrostatic interaction between amyloidogenic proteins and biomolecules plays a vital role in amyloidogenesis. In this work, we have measured and mapped the surface charge distributions of amyloids (i.e., β-lactoglobulin fibril) using Kelvin probe force microscopy. It is shown that the surface charge distribution is highly dependent on the conformation of amyloids (e.g., the helical pitch of amyloid fibrils) as well as the pH of a solvent.
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87.15.Pc Electronic and electrical properties
87.16.Nn Motor proteins (myosin, kinesin dynein)
87.14.em Fibrils (amyloids, collagen, etc.)
87.15.kr Protein-solvent interactions
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Taking whispering gallery-mode single virus detection and sizing to the limit

V. R. Dantham, S. Holler, V. Kolchenko, Z. Wan, and S. Arnold

Appl. Phys. Lett. 101, 043704 (2012); http://dx.doi.org/10.1063/1.4739473 (4 pages) | Cited 7 times

Online Publication Date: 27 July 2012

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We report the label-free detection and sizing by a microcavity of the smallest individual RNA virus, MS2, with a mass only ∼1% of InfluenzaA (6 vs. 512 ag). Although detection of such a small bio-nano-particle has been beyond the reach of a bare spherical microcavity, it was accomplished with ease (S/N = 8, Q = 4 × 105) using a single dipole stimulated plasmonic-nanoshell as a microcavity wavelength shift enhancer, providing an enhancement of ∼70×, in agreement with theory. Unique wavelength shift statistics are recorded consistent with an ultra-uniform genetically programmed substance that is drawn to the plasmonic hot spots by light-forces.
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87.85.Rs Nanotechnologies-applications
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
87.14.gn RNA
87.80.Ek Mechanical and micromechanical techniques

The discharge mode transition and O(5p1) production mechanism of pulsed radio frequency capacitively coupled plasma

X. Y. Liu, J. T. Hu, J. H. Liu, Z. L. Xiong, D. W. Liu, X. P. Lu, and J. J. Shi

Appl. Phys. Lett. 101, 043705 (2012); http://dx.doi.org/10.1063/1.4733662 (4 pages)

Online Publication Date: 27 July 2012

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The discharge mode transition from uniform plasma across the gas gap to the α mode happens at the rising phase of the pulsed radio frequency capacitively coupled plasma (PRF CCP). This transition is attributed to the fast increasing stochastic heating at the edge of sheath. In the second stage with the stable current and voltage amplitude, the consistency between experimental and numerical spatial-temporal 777 nm emission profile suggests that He* and He2* dominate the production of O(5p1) through dissociation and excitation of O2. Finally, the sterilization efficiency of PRF CCP is found to be higher than that of plasma jet.
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52.80.Hc Glow; corona
52.80.Pi High-frequency and RF discharges
52.25.Os Emission, absorption, and scattering of electromagnetic radiation
52.20.Hv Atomic, molecular, ion, and heavy-particle collisions
52.50.Dg Plasma sources
52.77.-j Plasma applications
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