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28 Jan 2013

Volume 102, Issue 4, Articles (04xxxx)

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Appl. Phys. Lett. 102, 041101 (2013); http://dx.doi.org/10.1063/1.4777564 (5 pages)

K. Winkler, C. Schneider, J. Fischer, A. Rahimi-Iman, M. Amthor, A. Forchel, S. Reitzenstein, S. Höfling, and M. Kamp
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A biristor based on a floating-body silicon nanowire for biosensor applications

Dong-Il Moon, Maxime Peycelon, Jee-Yeon Kim, Jae-Hyuk Ahn, Tae Jung Park, and Yang-Kyu Choi

Appl. Phys. Lett. 102, 043701 (2013); http://dx.doi.org/10.1063/1.4789904 (4 pages)

Online Publication Date: 29 January 2013

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A silicon nanowire (SiNW), which has been named “biristor” (bistable resistor), is demonstrated for biosensor applications. The SiNW is composed of three segments: n-type (source), p-type (floating-body), and n-type (drain). Its structure is based on a metal-oxide-semiconductor field-effect transistor without a gate. The biristor uses the uncovered floating-body as a sensing site, and it is triggered by impact ionization. A charge effect arising from biomolecules influences the triggering voltage, which is a sensing metric and changes the resistance of the SiNW. The biristor can be a promising candidate for biosensors in terms of complementary metal-oxide-semiconductor compatibility, low-cost, and compact density.
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85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
87.80.Ek Mechanical and micromechanical techniques
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
07.10.Cm Micromechanical devices and systems
84.32.Ff Conductors, resistors (including thermistors, varistors, and photoresistors)
85.30.Tv Field effect devices

Esophageal cancer detection based on tissue surface-enhanced Raman spectroscopy and multivariate analysis

Shangyuan Feng, Juqiang Lin, Zufang Huang, Guannan Chen, Weisheng Chen, Yue Wang, Rong Chen, and Haishan Zeng

Appl. Phys. Lett. 102, 043702 (2013); http://dx.doi.org/10.1063/1.4789996 (4 pages)

Online Publication Date: 29 January 2013

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The capability of using silver nanoparticle based near-infrared surface enhanced Raman scattering (SERS) spectroscopy combined with principal component analysis (PCA) and linear discriminate analysis (LDA) to differentiate esophageal cancer tissue from normal tissue was presented. Significant differences in Raman intensities of prominent SERS bands were observed between normal and cancer tissues. PCA-LDA multivariate analysis of the measured tissue SERS spectra achieved diagnostic sensitivity of 90.9% and specificity of 97.8%. This exploratory study demonstrated great potential for developing label-free tissue SERS analysis into a clinical tool for esophageal cancer detection.
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87.64.kp Raman
87.85.Ng Biological signal processing
87.19.xj Cancer
87.50.wf Biophysical mechanisms of interaction
87.64.km Infrared

Viscous forces are predominant in the zona pellucida mechanical resistance

Massimiliano Papi, Alessandro Maiorana, Cécile Douet, Giuseppe Maulucci, Tiziana Parasassi, Roberto Brunelli, Ghylène Goudet, and Marco De Spirito

Appl. Phys. Lett. 102, 043703 (2013); http://dx.doi.org/10.1063/1.4789503 (4 pages) | Cited 1 time

Online Publication Date: 30 January 2013

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The zona pellucida (ZP) is a multilayer glycoprotein spherical shell surrounding mammalian eggs. The ZP's mechanical response plays a crucial role in mammalian fertilization and is a parameter commonly adopted in “in vitro fertilization” to characterize the oocytes quality. While it is assumed that ZP mechanical response is purely elastic, here we prove that dissipative forces cannot be neglected. Physiologically, this evidence implies that an increase in the spermatozoa motility can induce dramatic changes on the ZP reaction force turning ZP shell in an impenetrable barrier leading to fertility impairments.
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87.16.dm Mechanical properties and rheology
87.16.dr Assembly and interactions
87.17.-d Cell processes
87.14.ep Membrane proteins

On the hydrophobicity of modified Ga-polar GaN surfaces

I. Dzięcielewski, J. L. Weyher, and W. Dzwolak

Appl. Phys. Lett. 102, 043704 (2013); http://dx.doi.org/10.1063/1.4790435 (3 pages)

Online Publication Date: 1 February 2013

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In this communication, we show that chemical modifications of etched GaN (with different morphological features) through treatment with trichlorododecylsilane or sputtering nano-Au films followed by covalent binding of 1-dodecanethiol strongly affect surface water repellency characteristics. Binding of 1-dodecanethiol to Au-coated whiskers results in GaN crystals becoming superhydrophobic with the contact angles approaching 150°. For a single type of surface morphology, a pairwise comparison of contact angle values of trichlorododecylsilane- and Au/1-dodecanethiol-modified surfaces provides an insight into relative abundance of –OH groups on GaN's Ga-polar side, which mediate and control binding of the hydrophobic silane compound, but not of thiols.
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81.05.Ea III-V semiconductors
81.65.Cf Surface cleaning, etching, patterning
68.35.bg Semiconductors
68.03.Cd Surface tension and related phenomena
68.08.Bc Wetting
79.20.Rf Atomic, molecular, and ion beam impact and interactions with surfaces
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