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4 Feb 2013

Volume 102, Issue 5, Articles (05xxxx)

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Appl. Phys. Lett. 102, 053102 (2013); http://dx.doi.org/10.1063/1.4789442 (5 pages)

P. H. Kim, C. Doolin, B. D. Hauer, A. J. R. MacDonald, M. R. Freeman, P. E. Barclay, and J. P. Davis
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Near-field optical microscopy with an infra-red free electron laser applied to cancer diagnosis

A. D. Smith, M. R. F. Siggel-King, G. M. Holder, A. Cricenti, M. Luce, P. Harrison, D. S. Martin, M. Surman, T. Craig, S. D. Barrett, A. Wolski, D. J. Dunning, N. R. Thompson, Y. Saveliev, D. M. Pritchard, et al.

Appl. Phys. Lett. 102, 053701 (2013); http://dx.doi.org/10.1063/1.4790436 (4 pages)

Online Publication Date: 4 February 2013

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We show that the combination of a scanning near field optical microscope and an infra-red free electron laser yields chemical images with sub-cellular spatial resolution that have the potential to provide a diagnostic for oesophageal adenocarcinoma.
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87.63.lt Laser imaging
42.62.Be Biological and medical applications
87.19.xj Cancer
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Determination of the complex dielectric constant of an epithelial cell monolayer in the terahertz region

K. Shiraga, Y. Ogawa, T. Suzuki, N. Kondo, A. Irisawa, and M. Imamura

Appl. Phys. Lett. 102, 053702 (2013); http://dx.doi.org/10.1063/1.4790392 (4 pages)

Online Publication Date: 5 February 2013

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We present a method to determine the complex dielectric constant of a cell monolayer using terahertz time-domain attenuated total reflection spectroscopy combined with a two-interface model. The imaginary part of the dielectric constant of the cell monolayer shows a lower absorption of slow relaxation mode than that of the liquid medium. This result allows us to estimate the intracellular water dynamics on a picosecond time scale, and the existence of weakly hydrated water molecules inside the cell monolayer was indicated. This method will provide a perspective to investigate the intracellular water dynamics in detail.
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87.16.dp Transport, including channels, pores, and lateral diffusion
07.57.Pt Submillimeter wave, microwave and radiowave spectrometers; magnetic resonance spectrometers, auxiliary equipment, and techniques
78.70.Gq Microwave and radio-frequency interactions
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Nanoscale structure of protamine/DNA complexes for gene delivery

Simona Motta, Paola Brocca, Elena Del Favero, Valeria Rondelli, Laura Cantù, Augusto Amici, Daniela Pozzi, and Giulio Caracciolo

Appl. Phys. Lett. 102, 053703 (2013); http://dx.doi.org/10.1063/1.4790588 (4 pages)

Online Publication Date: 5 February 2013

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Understanding the internal packing of gene carriers is a key-factor to realize both gene protection during transport and de-complexation at the delivery site. Here, we investigate the structure of complexes formed by DNA fragments and protamine, applied in gene delivery. We found that complexes are charge- and size-tunable aggregates, depending on the protamine/DNA ratio, hundred nanometers in size. Their compactness and fractal structure depend on the length of the DNA fragments. Accordingly, on the local scale, the sites of protamine/DNA complexation assume different morphologies, seemingly displaying clumping ability for the DNA network only for shorter DNA fragments.
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87.85.Rs Nanotechnologies-applications
87.14.E- Proteins
87.14.gk DNA
87.15.B- Structure of biomolecules
87.15.K- Molecular interactions; membrane-protein interactions
87.85.md Genetic engineering

Portable optical-resolution photoacoustic microscopy with a pulsed laser diode excitation

Lvming Zeng, Guodong Liu, Diwu Yang, and Xuanrong Ji

Appl. Phys. Lett. 102, 053704 (2013); http://dx.doi.org/10.1063/1.4791566 (4 pages) | Cited 1 time

Online Publication Date: 6 February 2013

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Optical-resolution photoacoustic microscopy (OR-PAM) has been significantly improved in terms of spatial resolution, detection sensitivity, imaging speed, and penetration depth. However, the popular producibility of OR-PAM system is still limited by the size and cost of solid-state laser excitation. Here, we developed a portable laser-diode-based OR-PAM (LD-OR-PAM) system using a pulsed semiconductor laser source, which was operated at 905 ± 15 nm with a pulse energy as low as 4.9 μJ. The measured lateral resolution has been improved to ∼1.5 μm from hundreds of microns. The compact and inexpensive natures of LD-OR-PAM would promote the potential clinical applications such as in dermatology.
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42.62.Eh Metrological applications; optical frequency synthesizers for precision spectroscopy
42.55.Px Semiconductor lasers; laser diodes
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