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11 Feb 2013

Volume 102, Issue 6, Articles (06xxxx)

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Appl. Phys. Lett. 102, 063701 (2013); http://dx.doi.org/10.1063/1.4790115 (5 pages)

In-Tsang Lin, Hong-Chang Yang, and Jyh-Horng Chen
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Diffusion tensor imaging using a high-temperature superconducting resonator in a 3 T magnetic resonance imaging for a spontaneous rat brain tumor

In-Tsang Lin, Hong-Chang Yang, and Jyh-Horng Chen

Appl. Phys. Lett. 102, 063701 (2013); http://dx.doi.org/10.1063/1.4790115 (5 pages)

Online Publication Date: 11 February 2013

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This study investigates the peri-tumor signal abnormalities of a spontaneous brain tumor in a rat by using a 4 cm high-temperature superconducting (HTS) surface resonator. Fractional anisotropy (FA) values derived from diffusion tensor imaging reflect the interstitial characteristic of the peri-lesional tissues of brain tumors. Low FA indicates interstitial tumor infiltration and tissue injury, while high FA indicates better tissue integrity. Better delineation of tissue contents obtained by the HTS surface resonator at 77 K may facilitate therapeutic strategy and improve clinical outcomes.
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87.61.-c Magnetic resonance imaging
87.19.L- Neuroscience
87.19.lf MRI: anatomic, functional, spectral, diffusion
87.19.xj Cancer
85.25.-j Superconducting devices

Thermoacoustic resonance effect and circuit modelling of biological tissue

Fei Gao, Yuanjin Zheng, Xiaohua Feng, and Claus-Dieter Ohl

Appl. Phys. Lett. 102, 063702 (2013); http://dx.doi.org/10.1063/1.4791791 (4 pages)

Online Publication Date: 11 February 2013

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In this letter, thermoacoustic resonance effect is predicted from theoretical analysis with series resistor-inductor-capacitor resonance circuit model and then observed experimentally using muscle tissue illuminated by multi-pulse microwave source. Through model fitting, the circuit parameters are extracted to characterize quantitatively the resonant response of the tissue. Coherent demodulation is applied to obtain the enhanced signal-to-noise ratio and spatial information by treating tissue as a communication channel. This physical phenomenon shows significantly higher sensitivity than conventional single microwave pulse induced thermoacoustic effect, enabling the potential design of low-power thermoacoustic imaging device for portable and on-site diagnosis.
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87.19.Pp Biothermics and thermal processes in biology
87.19.Ff Muscles

Breaking the acoustic diffraction limit via nonlinear effect and thermal confinement for potential deep-tissue high-resolution imaging

Baohong Yuan, Yanbo Pei, and Jayanth Kandukuri

Appl. Phys. Lett. 102, 063703 (2013); http://dx.doi.org/10.1063/1.4792736 (5 pages)

Online Publication Date: 14 February 2013

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Our recently developed ultrasound-switchable fluorescence (USF) imaging technique showed that it was feasible to conduct high-resolution fluorescence imaging in a centimeter-deep turbid medium. Because the spatial resolution of this technique highly depends on the ultrasound-induced temperature focal size (UTFS), minimization of UTFS becomes important for further improving the spatial resolution USF technique. In this study, we found that UTFS can be significantly reduced below the diffraction-limited acoustic intensity focal size via nonlinear acoustic effects and thermal confinement by appropriately controlling ultrasound power and exposure time, which can be potentially used for deep-tissue high-resolution imaging.
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87.63.dh Ultrasonographic imaging
02.60.Pn Numerical optimization
42.30.Va Image forming and processing
87.63.Hg Thermography
87.57.cf Spatial resolution
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