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21 Feb 2000

Volume 76, Issue 8, pp. 943-1075

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Microvolume field-effect pH sensor for the scanning probe microscope

S. R. Manalis, E. B. Cooper, P. F. Indermuhle, P. Kernen, P. Wagner, D. G. Hafeman, S. C. Minne, and C. F. Quate

Appl. Phys. Lett. 76, 1072 (2000); http://dx.doi.org/10.1063/1.125942 (3 pages) | Cited 9 times

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A pH sensitive scanning probe is realized by integrating a micron-sized field-effect sensor onto a cantilever designed for an atomic force microscope. The hybrid device, called a scanning probe potentiometer (SPP), is capable of measuring pH gradients over a sample surface. The device was used to profile the pH across a reservoir of laminar streams created by fluid flow in an array of microfluidic channels of varying pH. When a single SPP scanned, a 1.5 mm reservoir in a 10-channel array, the pH profile was measured in less than 1 min with a spatial resolution of 10 μm and sensitivity of less than 0.01 pH units. © 2000 American Institute of Physics.
Show PACS
07.79.Lh Atomic force microscopes
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
82.80.-d Chemical analysis and related physical methods of analysis
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