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4 Sep 2000

Volume 77, Issue 10, pp. 1413-1560

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Comparison of penetration depth between two-photon excitation and single-photon excitation in imaging through turbid tissue media

Min Gu, Xiaosong Gan, Aernout Kisteman, and Ming Gun Xu

Appl. Phys. Lett. 77, 1551 (2000); http://dx.doi.org/10.1063/1.1308059 (3 pages) | Cited 14 times

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We show, both theoretically and experimentally, that for a turbid tissue medium where Mie scattering is dominant, multiple scattering not only reduces the illumination power in the forward direction but also exhibits an anisotropic distribution of scattered photons. Thus, a signal level under two-photon excitation drops much faster than that under single-photon excitation although image resolution is much higher in the former case. As a result, the penetration depth under two-photon excitation is limited by the strength of two-photon fluorescence and is not necessarily larger than that under single-photon excitation. © 2000 American Institute of Physics.
Show PACS
87.63.L- Visual imaging
87.50.W- Optical/infrared radiation effects
42.25.Fx Diffraction and scattering
87.64.Cc Scattering of visible, uv, and infrared radiation
42.30.Va Image forming and processing
42.25.Dd Wave propagation in random media
42.62.Be Biological and medical applications
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