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14 Aug 2000

Volume 77, Issue 7, pp. 921-1064

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Optical observation of contrast agent destruction

James E. Chomas, Paul A. Dayton, Donovan May, John Allen, Alexander Klibanov, and Katherine Ferrara

Appl. Phys. Lett. 77, 1056 (2000); http://dx.doi.org/10.1063/1.1287519 (3 pages) | Cited 46 times

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Show Abstract
Fragmentation of an ultrasound contrast agent on the time scale of microseconds provides opportunities for the advancement of microvascular detection, blood flow velocity estimation, and targeted drug delivery. Images captured by high-speed imaging systems show destruction of a microbubble during compression. Peak wall velocity of −700 m/s and peak acceleration of 1.2×1012 m/s2 is observed for insonation with a peak pressure of −1.1 MPa and a center frequency of 2.4 MHz. Theoretical calculations of wall velocity and acceleration using a modified Rayleigh–Plesset model predict a peak negative wall velocity of −680 m/s and peak acceleration of 2×1012 m/s2. © 2000 American Institute of Physics.
Show PACS
43.80.Qf Medical diagnosis with acoustics
43.35.Wa Biological effects of ultrasound, ultrasonic tomography
87.63.L- Visual imaging
43.80.Vj Acoustical medical instrumentation and measurement techniques
87.50.Y- Biological effects of acoustic and ultrasonic energy
87.19.U- Hemodynamics
87.19.Wx Pneumodyamics, respiration
87.63.D- Ultrasonography
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