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19 Mar 2001

Volume 78, Issue 12, pp. 1649-1795

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Manipulation of magnetic microbeads in suspension using micromagnetic systems fabricated with soft lithography

Tao Deng, George M. Whitesides, Mala Radhakrishnan, Gary Zabow, and Mara Prentiss

Appl. Phys. Lett. 78, 1775 (2001); http://dx.doi.org/10.1063/1.1356728 (3 pages) | Cited 72 times

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Show Abstract
Current-carrying microcircuits can generate strong magnetic-field gradients; these gradients, in turn, can control the position of magnetic microbeads in aqueous suspension. Micromagnetic systems were prepared using two representative soft lithography techniques—micromolding in capillaries and microtransfer molding—combined with electrodeposition. They can capture microbeads from solution, hold them in a fixed position, and move them along complex paths. Simply changing the current flowing in the systems can dynamically reconfigure the paths. The manipulation of magnetic microbeads using microfabricated circuits should expand current sample handling capabilities for biotechnology and combinational technology with or without the presence of net fluid flow and microfluidic channels. © 2001 American Institute of Physics.
Show PACS
06.60.Sx Positioning and alignment; manipulating, remote handling
87.80.Fe Micromanipulation of biological structures
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
07.55.Db Generation of magnetic fields; magnets
75.50.Mm Magnetic liquids
81.15.Pq Electrodeposition, electroplating
81.10.Fq Growth from melts; zone melting and refining
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