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3 Dec 2001

Volume 79, Issue 23, pp. 3749-3889

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Three-dimensional thermal noise imaging

Christian Tischer, Stephan Altmann, Samo Fisinger, J. K. Heinrich Hörber, Ernst H. K. Stelzer, and Ernst-Ludwig Florin

Appl. Phys. Lett. 79, 3878 (2001); http://dx.doi.org/10.1063/1.1423404 (3 pages) | Cited 22 times

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We present a scanning probe microscope based on optical tweezers for three-dimensional imaging of the topology of transparent material in the nanometer range. A spherical nanoparticle serves as a probe. An optical trap moves it through the sample (e.g., a polymer network), while the position of the particle center is recorded by three-dimensional interferometry. Accessible volumes are reconstructed from the histogram of thermal position fluctuations of the particle. The resolution in determining the position of surfaces in three dimensions is about 20 nm. © 2001 American Institute of Physics.
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07.79.-v Scanning probe microscopes and components
87.64.Dz Scanning tunneling and atomic force microscopy

Insulating behavior for DNA molecules between nanoelectrodes at the 100 nm length scale

A. J. Storm, J. van Noort, S. de Vries, and C. Dekker

Appl. Phys. Lett. 79, 3881 (2001); http://dx.doi.org/10.1063/1.1421086 (3 pages) | Cited 166 times

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Electrical transport measurements are reported for double-stranded DNA molecules located between nanofabricated electrodes. We observe the absence of any electrical conduction through these DNA-based devices, both at the single-molecule level as well as for small bundles of DNA. We obtain a lower bound of 10 TΩ for the resistance of a DNA molecule at length scales larger than 40 nm. It is concluded that DNA is insulating. This conclusion is based on an extensive set of experiments in which we varied key parameters such as the base-pair sequence [mixed sequence and homogeneous poly(dG)⋅poly(dC)], length between contacts (40–500 nm), substrate (SiO2 or mica), electrode material (gold or platinum), and electrostatic doping fields. Discrepancies with other reports in the literature are discussed. © 2001 American Institute of Physics.
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85.65.+h Molecular electronic devices
87.14.G- Nucleic acids
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