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31 Dec 2001

Volume 79, Issue 27, pp. 4479-4603

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Optical transport of a single cell-sized liposome

Masatoshi Ichikawa and Kenichi Yoshikawa

Appl. Phys. Lett. 79, 4598 (2001); http://dx.doi.org/10.1063/1.1430026 (3 pages) | Cited 19 times

Online Publication Date: 13 March 2002

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Show Abstract
A closed phospholipid membrane vesicle, or giant liposome, with a diameter of ∼10 μm, constitutes a model of a living cell. Since the phospholipid membrane is about 5 nm thick, it is extremely difficult to trap an individual giant liposome with a laser. We report here the intact transport of an individual cell-sized liposome using an infrared laser. It is shown that the optical attractive potential on a liposome with an inner solution of higher refractivity is about one order of magnitude greater than that of a liposome with the same solution both inside and outside. Since this cell-sized liposome is rather stable, the optical manipulation of liposomes could be useful for the realization of a μm-scaled laboratory for use in biochemistry and molecular biology. © 2001 American Institute of Physics.
Show PACS
87.80.Cc Optical trapping
87.16.D- Membranes, bilayers, and vesicles
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