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27 May 2002

Volume 80, Issue 21, pp. 3883-4065

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Protein detection by optical shift of a resonant microcavity

F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, and S. Arnold

Appl. Phys. Lett. 80, 4057 (2002); http://dx.doi.org/10.1063/1.1482797 (3 pages) | Cited 230 times

Online Publication Date: 20 May 2002

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We present an optical biosensor with unprecedented sensitivity for detection of unlabeled molecules. Our device uses optical resonances in a dielectric microparticle (whispering gallery modes) as the physical transducing mechanism. The resonances are excited by evanescent coupling to an eroded optical fiber and detected as dips in the light intensity transmitted through the fiber at different wavelengths. Binding of proteins on the microparticle surface is measured from a shift in resonance wavelength. We demonstrate the sensitivity of our device by measuring adsorption of bovine serum albumin and we show its use as a biosensor by detecting streptavidin binding to biotin. © 2002 American Institute of Physics.
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87.80.-y Biophysical techniques (research methods)
87.14.E- Proteins
42.81.Pa Sensors, gyros

Protein-based integrated optical switching and modulation

Pál Ormos, László Fábián, László Oroszi, Elmar K. Wolff, Jeremy J. Ramsden, and András Dér

Appl. Phys. Lett. 80, 4060 (2002); http://dx.doi.org/10.1063/1.1481197 (3 pages) | Cited 28 times

Online Publication Date: 20 May 2002

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The static and dynamic response of optical waveguides coated with a thin protein film of bacteriorhodopsin was investigated. The size and kinetics of the light-induced refractive index changes of the adlayer were determined under different conditions of illumination. The results demonstrate the applicability of this protein as an active, programmable nonlinear optical material in all-optical integrated circuits. © 2002 American Institute of Physics.
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42.82.Et Waveguides, couplers, and arrays
42.70.Jk Polymers and organics
87.14.E- Proteins
81.05.Lg Polymers and plastics; rubber; synthetic and natural fibers; organometallic and organic materials
87.15.M- Spectra of biomolecules
42.70.Nq Other nonlinear optical materials; photorefractive and semiconductor materials
42.79.Wc Optical coatings
78.66.Qn Polymers; organic compounds
42.65.Pc Optical bistability, multistability, and switching, including local field effects
42.79.Hp Optical processors, correlators, and modulators
42.65.Wi Nonlinear waveguides
42.79.Gn Optical waveguides and couplers
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