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21 Jul 2003

Volume 83, Issue 3, pp. 407-587

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Appl. Phys. Lett. 83, 575 (2003); http://dx.doi.org/10.1063/1.1594830 (3 pages)

P. Yu, M. Mustata, J. J. Turek, P. M. W. French, M. R. Melloch, and D. D. Nolte
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Holographic optical coherence imaging of tumor spheroids

P. Yu, M. Mustata, J. J. Turek, P. M. W. French, M. R. Melloch, and D. D. Nolte

Appl. Phys. Lett. 83, 575 (2003); http://dx.doi.org/10.1063/1.1594830 (3 pages) | Cited 26 times

Online Publication Date: 16 July 2003

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We present depth-resolved coherence-domain images of living tissue using a dynamic holographic semiconductor film. An AlGaAs photorefractive quantum-well device is used in an adaptive interferometer that records coherent backscattered (image-bearing) light from inside rat osteogenic sarcoma tumor spheroids up to 1 mm in diameter in vitro. The data consist of sequential holographic image frames at successive depths through the tumor represented as a visual video “fly-through.” The images from the tumor spheroids reveal heterogeneous structures presumably caused by necrosis and microcalcifications characteristic of human tumors in their early avascular growth. © 2003 American Institute of Physics.
Show PACS
87.63.L- Visual imaging
85.35.Be Quantum well devices (quantum dots, quantum wires, etc.)
42.40.My Applications
87.19.X- Diseases
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