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12 Apr 2004

Volume 84, Issue 15, pp. 2721-2955

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Appl. Phys. Lett. 84, 2883 (2004); http://dx.doi.org/10.1063/1.1702137 (3 pages)

Pu Xian Gao and Zhong L. Wang
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Investigation of laser-induced cell lysis using time-resolved imaging

Kaustubh R. Rau, Arnold Guerra, Alfred Vogel, and Vasan Venugopalan

Appl. Phys. Lett. 84, 2940 (2004); http://dx.doi.org/10.1063/1.1705728 (3 pages) | Cited 28 times

Online Publication Date: 7 April 2004

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Using time-resolved imaging, we investigated the lysis of confluent PtK2 cell cultures by pulsed laser microbeam irradiation. Images obtained at time delays of 0.5 ns to 50 μs demonstrate lysis to be mediated by laser-induced plasma formation resulting in pressure wave propagation and cavitation bubble formation. Image analysis enabled quantitative characterization of the pressure wave and cavitation bubble dynamics. The zone of cell damage exceeded the plasma size and serves to implicate cavitation bubble expansion as the primary agent of cell injury. © 2004 American Institute of Physics.
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87.85.J- Biomaterials
87.50.-a Effects of electromagnetic and acoustic fields on biological systems
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