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19 Apr 2004

Volume 84, Issue 16, pp. 2971-3207

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Appl. Phys. Lett. 84, 3139 (2004); http://dx.doi.org/10.1063/1.1710717 (3 pages)

Slava V. Rotkin and Karl Hess
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Effect of mass and stress on resonant frequency shift of functionalized Pb(Zr0.52Ti0.48)O3 thin film microcantilever for the detection of C-reactive protein

Jeong Hoon Lee, Tae Song Kim, and Ki Hyun Yoon

Appl. Phys. Lett. 84, 3187 (2004); http://dx.doi.org/10.1063/1.1712028 (3 pages) | Cited 63 times

Online Publication Date: 13 April 2004

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A micromachined PZT (52/48) thin film cantilever composed of SiO2/Ta/Pt/PZT/Pt/SiO2 on a SiNx supporting layer for simultaneous self-exciting and sensing was fabricated. We present the resonant frequency change of piezoelectric microcantilevers due to a combination of mass loading and spring constant variation arisen from antigen-antibody interaction of C-reactive protein (CRP). Experimentally measured resonant frequency shift is larger than that of theoretically calculated resonant frequency by two orders of magnitude due to a compressive stress arising from CRP antigen-antibody interaction. The changes in normalized resonant frequency shift δf expt/f1 expt were found to increase as the value of 40.5, 74.7, and 185×10−4 as the CRP antibody site ratio, increased 10%, 50%, and 100%, respectively. © 2004 American Institute of Physics.
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77.55.-g Dielectric thin films
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
87.85.Va Micromachining

High-resolution imaging of cardiac biomagnetic fields using a low-transition-temperature superconducting quantum interference device microscope

L. E. Fong, J. R. Holzer, K. McBride, E. A. Lima, F. Baudenbacher, and M. Radparvar

Appl. Phys. Lett. 84, 3190 (2004); http://dx.doi.org/10.1063/1.1704871 (3 pages) | Cited 5 times

Online Publication Date: 13 April 2004

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We have developed a multiloop low-temperature superconducting quantum interference device sensor with a field sensitivity of 450 fT/Hz−1/2 for imaging biomagnetic fields generated by action currents in cardiac tissue. The sensor has a diameter of 250 μm and can be brought to within 100 μm of a room-temperature sample. Magnetic fields generated by planar excitation waves are associated with a current component parallel to the wave front, in agreement with predictions of the bidomain model. Our findings provide a new basis for interpreting the magnetocardiogram. © 2004 American Institute of Physics.
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87.50.C- Static and low-frequency electric and magnetic fields effects
85.25.Dq Superconducting quantum interference devices (SQUIDs)
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing
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