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1 Mar 2004

Volume 84, Issue 9, pp. 1435-1613

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Appl. Phys. Lett. 84, 1558 (2004); http://dx.doi.org/10.1063/1.1651641 (3 pages)

DongWeon Lee, Adrian Wetzel, Roland Bennewitz, Ernst Meyer, Michel Despont, Peter Vettiger, and Christoph Gerber
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DNA detection on transistor arrays following mutation-specific enzymatic amplification

F. Pouthas, C. Gentil, D. Côte, and U. Bockelmann

Appl. Phys. Lett. 84, 1594 (2004); http://dx.doi.org/10.1063/1.1650907 (3 pages) | Cited 50 times

Online Publication Date: 25 February 2004

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An integrated array of silicon field-effect transistor structures is used for electronic detection of label-free DNA. Measurements of the dc current–voltage characteristics of the transistors gives us access to reproducible detection of single- and double-stranded DNA, locally adsorbed on the surface of the device. We combine this approach with allele-specific polymerase chain reaction, to test for the 35delG mutation, a frequent mutation related to prelingual nonsyndromic deafness. © 2004 American Institute of Physics.
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87.14.G- Nucleic acids
85.30.Tv Field effect devices
85.45.Db Field emitters and arrays, cold electron emitters

Ultrasound-modulated optical computed tomography of biological tissues

Jun Li and Lihong V. Wang

Appl. Phys. Lett. 84, 1597 (2004); http://dx.doi.org/10.1063/1.1651330 (3 pages) | Cited 12 times

Online Publication Date: 25 February 2004

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An optical imaging technique called ultrasound-modulated optical computed tomography is demonstrated for tomographic imaging of biological tissues. Ultrasound-modulated optical signals are extracted from scattered light to provide projection data for the image reconstruction. A filtered back-projection algorithm is implemented to reconstruct an image reflecting optical tissue properties from angular and linear scans of an ultrasonic beam across a sample. This reconstruction-based imaging technique provides a way to obtain images of cross sections containing the scanned ultrasonic axis in biological tissues, which enables three-dimensional ultrasound-modulated optical imaging. The technique combines the contrast advantage of optical waves and the resolution advantage of ultrasonic waves. © 2004 American Institute of Physics.
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42.30.Wb Image reconstruction; tomography
43.35.Wa Biological effects of ultrasound, ultrasonic tomography
87.63.L- Visual imaging
87.63.D- Ultrasonography
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