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16 Aug 2004

Volume 85, Issue 7, pp. 1095-1302

Issue Cover Spotlight Figure

Appl. Phys. Lett. 85, 1277 (2004); http://dx.doi.org/10.1063/1.1783021 (3 pages)

Katsuhiko Nishiguchi, Hiroshi Inokawa, Yukinori Ono, Akira Fujiwara, and Yasuo Takahashi
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Random lasing in human tissues

Randal C. Polson and Z. Valy Vardeny

Appl. Phys. Lett. 85, 1289 (2004); http://dx.doi.org/10.1063/1.1782259 (3 pages) | Cited 65 times

Online Publication Date: 10 August 2004

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A random collection of scatterers in a gain medium can produce coherent laser emission lines dubbed “random lasing.” We show that biological tissues, including human tissues, can support coherent random lasing when infiltrated with a concentrated laser dye solution. To extract a typical random resonator size within the tissue we average the power Fourier transform of random laser spectra collected from many excitation locations in the tissue; we verified this procedure by a computer simulation. Surprisingly, we found that malignant tissues show many more laser lines compared to healthy tissues taken from the same organ. Consequently, the obtained typical random resonator was found to be different for healthy and cancerous tissues, and this may lead to a technique for separating malignant from healthy tissues for diagnostic imaging.
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87.15.M- Spectra of biomolecules
78.45.+h Stimulated emission
87.57.-s Medical imaging
87.57.U- Nuclear medicine imaging
42.55.Mv Dye lasers
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