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11 Apr 2005

Volume 86, Issue 15, Articles (15xxxx)

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Appl. Phys. Lett. 86, 152101 (2005); http://dx.doi.org/10.1063/1.1897831 (3 pages)

Walid Hafez and Milton Feng
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Direct current electrical characterization of ds-DNA in nanogap junctions

Samir M. Iqbal, G. Balasundaram, Subhasis Ghosh, D. E. Bergstrom, and R. Bashir

Appl. Phys. Lett. 86, 153901 (2005); http://dx.doi.org/10.1063/1.1900315 (3 pages) | Cited 33 times

Online Publication Date: 5 April 2005

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Measurements of DNA conductivity, hybridization, and melting using electronic means can have wide applications in molecular electronics and biological sensors. We have fabricated nanogap break-junctions by electromigration through thin gold-on-titanium films. 18-mer thiolated ds-DNA molecules were covalently attached between the electrodes and dc electrical measurements were done. The conductance was measured through the molecule before and after a temperature ramp from 300 to 400 K. A dramatic decrease in conductance was observed, analogous to an electrical fuse, possibly attributed to complete or partial denaturing of the ds-DNA molecules bridging the nanogaps. We also show evidence that the dc resistance of dry DNA strands of the same length decreases with increasing guanine-cytosine content in the sequence with values ranging from 10 M Ω to 2 G Ω. These findings can have important consequences in DNA-based molecular electronics and direct label-free detection of DNA hybridization.
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87.14.G- Nucleic acids
87.15.B- Structure of biomolecules
87.15.Vv Diffusion
85.65.+h Molecular electronic devices

Discrimination between normal and cancer cells by using spectral analysis of delayed luminescence.

Francesco Musumeci, Giuseppe Privitera, Agata Scordino, Salvatore Tudisco, Carmine Lo Presti, Lee Ann Applegate, and Hugo J. Niggli

Appl. Phys. Lett. 86, 153902 (2005); http://dx.doi.org/10.1063/1.1900317 (3 pages) | Cited 7 times

Online Publication Date: 5 April 2005

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In our present studies, the time-resolved emission spectrum of delayed luminescence of cell cultures of human fibroblast and human melanoma have been measured using a sophisticated single photon device. Noticeable differences have been found both in the emission spectra, which are time dependent, and in the timing aspects of the different spectral components. This powerful and noninvasive technique can be applied in all fields of skin research, such as the investigation of skin abnormalities and to test the effect of products involved in regeneration, antiaging, and UV-light protection in order to prevent skin cancer.
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