APL Nameplate
  • Volume/Page
  • Keyword
  • DOI
  • Citation
  • Advanced
   
 
 
 

Flickr Twitter iResearch App Facebook

BROWSE VOLUMES

Year Range: 
Search Issue | RSS Feeds RSS
Previous Issue Next Issue

19 Sep 2005

Volume 87, Issue 12, Articles (12xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 87, 123111 (2005); http://dx.doi.org/10.1063/1.2053370 (3 pages)

Xianghui Zhang, Ye Zhang, Jun Xu, Zhe Wang, Xihong Chen, Dapeng Yu, Peng Zhang, Hanhong Qi, and Yongjun Tian
Enlarge Image | Read More
Return to All Sections
back to top
RSS Feeds

Light-induced cell separation in a tailored optical landscape

L. Paterson, E. Papagiakoumou, G. Milne, V. Garcés-Chávez, S. A. Tatarkova, W. Sibbett, F. J. Gunn-Moore, P. E. Bryant, A. C. Riches, and K. Dholakia

Appl. Phys. Lett. 87, 123901 (2005); http://dx.doi.org/10.1063/1.2045548 (3 pages) | Cited 47 times

Online Publication Date: 13 September 2005

Full Text: Read Online (HTML) | Download PDF

Show Abstract
We demonstrate passive optical sorting of cell populations in the absence of any externally driven fluid flow. Specifically, we report the movement of erythrocytes and lymphocytes in an optical landscape, consisting of a circularly symmetric light pattern created by a Bessel light beam. These distinct cell populations move, spontaneously and differentially, across the underlying periodic optical landscape. Thus, we were able to separate lymphocytes from a mixed population of cells containing erythrocytes and then collect the lymphocytes in a microcapillary reservoir. We also demonstrate an enhanced form of this separation that exploits the polarizability of silica microspheres by attaching spheres coated with antibodies to cell surface markers to a subpopulation of lymphocytes. These techniques may be applied using standard laboratory apparatus.
Show PACS
87.50.W- Optical/infrared radiation effects
87.80.Cc Optical trapping
Return to All Sections
Close

Google Calendar

ADVERTISEMENT

Go to AIP Home   © AIP Publishing LLC
close