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3 Oct 2005

Volume 87, Issue 14, Articles (14xxxx)

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Appl. Phys. Lett. 87, 143902 (2005); http://dx.doi.org/10.1063/1.2077839 (3 pages)

Kaustubh D. Bhalerao, Edward Eteshola, Matthew Keener, and Stephen C. Lee
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Optical detection of deoxyribonucleic acid hybridization using an anchoring transition of liquid crystal alignment

Hak-Rin Kim, Jae-Hoon Kim, Tae-Sun Kim, Sang-Wook Oh, and Eui-Yul Choi

Appl. Phys. Lett. 87, 143901 (2005); http://dx.doi.org/10.1063/1.2077859 (3 pages) | Cited 10 times

Online Publication Date: 27 September 2005

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We demonstrate an optical method for detecting specific binding events in an oligo deoxyribonucleic acid (DNA) chip using an anchoring transition of a nematic liquid crystal (NLC) as a result of DNA hybridization. A homeotropic orientation of the NLC supported by oligoDNA changes to a random planar orientation after hybridization. Such DNA hybridization and subsequent NLC reorientation are easily observable with a simple detection system via long-range orientational order and large optical anisotropy of the NLC.
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87.14.G- Nucleic acids
87.80.-y Biophysical techniques (research methods)
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing

Nanodevice design through the functional abstraction of biological macromolecules

Kaustubh D. Bhalerao, Edward Eteshola, Matthew Keener, and Stephen C. Lee

Appl. Phys. Lett. 87, 143902 (2005); http://dx.doi.org/10.1063/1.2077839 (3 pages)

Online Publication Date: 27 September 2005

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Biologic macromolecules are prefabricated, functional nanocomponents readily incorporated into nanodevices. Semibiologic nanodevice design typically depends on knowledge of specific biomolecules by individual biologist designers, so individual devices seldom take full advantage of available biodiversity and are poorly optimized. Available informational resources (proteomic and genomic databases) were built to reflect evolutionary relationships between organisms, molecules, and biologic systems, and are lacking in their explicit functional properties. This limits their direct utility in nanodevice design. We discuss the need, and possible structure for an information framework that captures the function of biological macromolecules to enable rational nanodevice design and optimization.
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87.80.-y Biophysical techniques (research methods)
87.14.E- Proteins
89.20.Hh World Wide Web, Internet
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