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24 Oct 2005

Volume 87, Issue 17, Articles (17xxxx)

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Appl. Phys. Lett. 87, 172506 (2005); http://dx.doi.org/10.1063/1.2120911 (3 pages)

T. Kimura, Y. Otani, and J. Hamrle
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Carbon nanotube probes for single-cell experimentation and assays

N. A. Kouklin, W. E. Kim, A. D. Lazareck, and J. M. Xu

Appl. Phys. Lett. 87, 173901 (2005); http://dx.doi.org/10.1063/1.2112183 (3 pages) | Cited 36 times

Online Publication Date: 19 October 2005

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Integrating nanotechnology with experimental biology is paramount to advancing fundamental biological science and technology, and, therefore, of high current interest and importance. In this article, we report on a new possibility of utilizing carbon nanotube probes assembled by a modified dielectrophoretic based technique for single-cell experimentation and delivery. The modified approach permits highly reproducible construction of water-stable, highly-aligned, and electrically-conductive probes several hundred microns in length, which hold a great promise for enhancing previously developed molecular-scale intracellular experimental techniques. The results of this work, in particular, indicate that the minimally invasive nanotube probes could be advantageous for studies involving permeabilization and subsequent desorption of molecules into a cell’s interior, thereby obviating permeabilization and diffusion across membranes.
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87.85.Qr Nanotechnologies-design
87.85.Rs Nanotechnologies-applications
87.16.D- Membranes, bilayers, and vesicles
87.16.Uv Active transport processes
87.17.-d Cell processes
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