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7 Nov 2005

Volume 87, Issue 19, Articles (19xxxx)

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Appl. Phys. Lett. 87, 192502 (2005); http://dx.doi.org/10.1063/1.2128478 (3 pages)

Ki-Suk Lee, SangKook Choi, and Sang-Koog Kim
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Activation of Na+ channels in cell membrane by capacitive stimulation with silicon chip

Ingmar Schoen and Peter Fromherz

Appl. Phys. Lett. 87, 193901 (2005); http://dx.doi.org/10.1063/1.2126803 (3 pages) | Cited 3 times

Online Publication Date: 2 November 2005

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Sodium channels are the crucial electrical elements of neuronal excitation. As a step toward hybrid neuron-semiconductor devices, we studied the activation of recombinant NaV1.4 sodium channels in human embryonic kidney (HEK293) cells by stimulation from an electrolyte/oxide/silicon (EOS) capacitor. HfO2 was used as an insulator to attain a high capacitance. An effective activation was achieved by decaying voltage ramps at constant intracellular voltage at a depleted NaCl concentration in the bath to enhance the resistance of the cell-chip contact. We were also able to open sodium channels at a NaCl concentration close to physiological conditions. This experiment provides a basis for noninvasive capacitive stimulation of nerve cells with semiconductor chips.
Show PACS
87.17.-d Cell processes
87.16.D- Membranes, bilayers, and vesicles
87.16.Uv Active transport processes
82.45.Gj Electrolytes
84.32.Tt Capacitors
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