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28 Nov 2005

Volume 87, Issue 22, Articles (22xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 87, 221108 (2005); http://dx.doi.org/10.1063/1.2137458 (3 pages)

V. Barna, S. Ferjani, A. De Luca, R. Caputo, N. Scaramuzza, C. Versace, and G. Strangi
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Molecular weight dependence of a whispering gallery mode biosensor

M. Noto, M. Khoshsima, D. Keng, I. Teraoka, V. Kolchenko, and S. Arnold

Appl. Phys. Lett. 87, 223901 (2005); http://dx.doi.org/10.1063/1.2137902 (3 pages) | Cited 14 times

Online Publication Date: 23 November 2005

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We report on molecular weight dependence measurements for an optical resonance biosensor. A dielectric microparticle is evanescently coupled with an optical fiber for the resonance stimulation, and a shift of the resonance wavelength is measured to monitor protein monolayer formation on the microparticle surface. Wavelength shifts for proteins over two orders of magnitude in molecular weight are measured. We show that the shift is proportional to molecular weight to the one-third power. Our result demonstrates that the optical resonance biosensor provides protein size information upon detection. This molecular weight dependency differentiates optical resonance sensing from electrical detection using field-effect transistors.
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87.80.-y Biophysical techniques (research methods)
87.15.M- Spectra of biomolecules
87.14.E- Proteins
42.81.Pa Sensors, gyros
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