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Applied Physics Letters / Volume 88 / Issue 12 / NANOSCALE SCIENCE AND DESIGN

Appl. Phys. Lett. 88, 123114 (2006); http://dx.doi.org/10.1063/1.2186967 (3 pages)

Field-effect control of protein transport in a nanofluidic transistor circuit

Rohit Karnik1, Kenneth Castelino1, and Arun Majumdar2

1Department of Mechanical Engineering, University of California, Berkeley, California 94720
2Department of Mechanical Engineering, University of California, Berkeley, California 94720 and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720

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(Received 29 September 2005; accepted 31 January 2006; published online 24 March 2006)

Electrostatic interactions play an important role in nanofluidic channels when the channel size is comparable to the Debye screening length. Electrostatic fields have been used to control concentration and transport of ions in nanofluidic transistors. Here, we report a transistor-reservoir-transistor circuit that can be used to turn “on” or “off” protein transport using electrostatic fields with gate voltages of ±1 V. Our results suggest that global electrostatic interactions of the protein were dominant over other interactions in the nanofluidic transistor. The fabrication technique also demonstrates the feasibility of nanofluidic integrated circuits for the manipulation of biomolecules in picoliter volumes.

© 2006 American Institute of Physics

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KEYWORDS and PACS

Keywords

proteins, molecular biophysics, biotransport, microfluidics, bioelectric potentials, nanotechnology, field effect transistor circuits

PACS

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.2186967

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

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    References

    D. Stein, M. Kruithof, and C. Dekker, Phys. Rev. Lett. 93, 035901 (2004).

    R. Fan, Y. Min, R. Karnik, A. Majumdar, and P. Yang, Phys. Rev. Lett. 95, 086607 (2005).


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