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20 Mar 2006

Volume 88, Issue 12, Articles (12xxxx)

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Appl. Phys. Lett. 88, 122510 (2006); http://dx.doi.org/10.1063/1.2186947 (3 pages)

P. Martín Pimentel, S. J. Hermsdoerfer, H. T. Nembach, B. Leven, B. Hillebrands, S. Trellenkamp, and S. Wolff
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Activation of a photosensitive pharmaceutical agent by a triboluminescent material

Stacey Yuen, Magdalena Schreyer, W. H. Finlay, R. Löbenberg, and W. Moussa

Appl. Phys. Lett. 88, 123901 (2006); http://dx.doi.org/10.1063/1.2189146 (3 pages)

Online Publication Date: 24 March 2006

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Given the recent emphasis on applications of triboluminescent materials, we investigate the ability of a triboluminescent material to activate a photosensitive pharmaceutical agent. Using compressed sucrose doped with wintergreen, which luminesces when fractured, we demonstrate the activation of riboflavin (vitamin B2), a photosensitizer. A product of activation is the highly reactive singlet oxygen. We add ascorbic acid (vitamin C), an antioxidant, and measure the amount of ascorbic acid oxidation to correlate with the amount of riboflavin activation. Up to 17% ascorbic acid oxidation is observed, indicating triboluminescence is worth exploring as a mechanism for activation of photosensitizers in photodynamic therapy.
Show PACS
87.50.wp Therapeutic applications
82.50.-m Photochemistry
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