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Applied Physics Letters / Volume 88 / Issue 16 / INTERDISCIPLINARY AND GENERAL PHYSICS

Appl. Phys. Lett. 88, 164103 (2006); http://dx.doi.org/10.1063/1.2191096 (3 pages)

A quantum mechanical scheme to reduce radiation damage in electron microscopy

Hiroshi Okamoto, Tatiana Latychevskaia, and Hans-Werner Fink

Institute of Physics, University of Zurich, Winterthurerstrasse 190, Zurich CH-8057, Switzerland

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(Received 1 August 2005; accepted 7 March 2006; published online 19 April 2006)

We show that radiation damage to unstained biological specimens is not an intractable problem in electron microscopy. When a structural hypothesis of a specimen is available, quantum mechanical principles allow us to verify the hypothesis with a very low electron dose. Realization of such a concept requires precise control of the electron wave front. Based on a diffractive electron optical implementation, we demonstrate the feasibility of this new method by both experimental and numerical investigations.

© 2006 American Institute of Physics

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KEYWORDS and PACS

Keywords

biological techniques, electron microscopy, quantum theory, radiation effects

PACS

  • 87.64.Ee

    Electron microscopy

  • 87.80.-y

    Biophysical techniques (research methods)

ARTICLE DATA

Digital Object Identifier
http://dx.doi.org/10.1063/1.2191096

PUBLICATION DATA

ISSN

0003-6951 (print)  
1077-3118 (online)

Publisher

$abstract.society.value is a Member of CrossRef American Institute of Physics

For access to fully linked references, you need to log in.
    J. Miao, T. Ohsuna, O. Terasaki, K. O. Hodfson, and M. A. O'Keefe, Phys. Rev. Lett. 89, 155502 (2002).

    H.-W. Fink, W. Stocker, and H. Schmid, Phys. Rev. Lett. 65, 1204 (1990).


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