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16 Oct 2006

Volume 89, Issue 16, Articles (16xxxx)

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Appl. Phys. Lett. 89, 164101 (2006); http://dx.doi.org/10.1063/1.2362602 (3 pages)

Yen-Wen Lu and Chang-Jin(CJ) Kim
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Label-free DNA sequence detection using oligonucleotide functionalized optical fiber

Xingwei Wang, Kristie L. Cooper, Anbo Wang, Juncheng Xu, Zhuang Wang, Yan Zhang, and Zhijian Tu

Appl. Phys. Lett. 89, 163901 (2006); http://dx.doi.org/10.1063/1.2364459 (3 pages) | Cited 12 times

Online Publication Date: 20 October 2006

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The authors present a label-free method for direct detection of deoxyribonucleic acid (DNA) sequences. The capture DNA is immobilized onto the surface of a silica optical fiber tip by means of the layer-by-layer electrostatic self-assembly technique. Hybridization of target DNA with complementary capture DNA increases the optical thickness of the fiber tip. This phenomenon can be detected by demodulation of the spectrum of a Fabry-Pérot cavity fabricated in the optical fiber. Experimental results demonstrate sequence specificity and sensitivity to nanogram quantities of target DNA sequences with short ( ∼ 5 min) hybridization time.
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87.80.-y Biophysical techniques (research methods)
87.15.Cc Folding: thermodynamics, statistical mechanics, models, and pathways
87.14.G- Nucleic acids
36.20.Fz Constitution (chains and sequences)
42.81.Pa Sensors, gyros

Dielectrophoretic force and torque on a sphere in an arbitrary time varying electric field

C. Y. Yang and U. Lei

Appl. Phys. Lett. 89, 163902 (2006); http://dx.doi.org/10.1063/1.2364468 (3 pages) | Cited 4 times

Online Publication Date: 20 October 2006

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The dielectrophoretic force and torque on a sphere were derived in an arbitrary time varying electric field using the effective moment method. The results depend on the local instantaneous electric field felt by the particle and the polarization history experienced by the particle. The polarization history effect is significant for a moving particle when it is traveling with a sufficiently high speed, when it is traveling across a nonuniform field with a sufficiently small length scale, or when the applied electric frequency is relatively low. The results may find application in the ac electrokinetic manipulation of particles and cells.
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47.65.-d Magnetohydrodynamics and electrohydrodynamics
47.61.Fg Flows in micro-electromechanical systems (MEMS) and nano-electromechanical systems (NEMS)
47.55.Kf Particle-laden flows
47.57.jd Electrokinetic effects
47.85.Np Fluidics
02.60.Cb Numerical simulation; solution of equations

Discrimination of microbiological samples using femtosecond laser-induced breakdown spectroscopy

Matthieu Baudelet, Jin Yu, Myriam Bossu, Julien Jovelet, Jean-Pierre Wolf, Tanguy Amodeo, Emeric Fréjafon, and Patrick Laloi

Appl. Phys. Lett. 89, 163903 (2006); http://dx.doi.org/10.1063/1.2361270 (3 pages) | Cited 22 times

Online Publication Date: 20 October 2006

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Using femtosecond laser-induced breakdown spectroscopy, the authors have analyzed five different species of bacterium. Line emissions from six trace mineral elements, Na, Mg, P, K, Ca, and Fe, have been clearly detected. Their intensities correspond to relative concentrations of these elements contained in the analyzed samples. The authors demonstrate that the concentration profile of trace elements allows unambiguous discrimination of different bacteria. Quantitative differentiation has been made by representing bacteria in a six-dimension hyperspace with each of its axis representing a detected trace element. In such hyperspace, representative points of different species of bacterium are gathered in different and distinct volumes.
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87.64.-t Spectroscopic and microscopic techniques in biophysics and medical physics
87.80.-y Biophysical techniques (research methods)
87.17.Ee Growth and division
42.65.Re Ultrafast processes; optical pulse generation and pulse compression
42.62.Be Biological and medical applications
82.80.-d Chemical analysis and related physical methods of analysis
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