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30 Oct 2006

Volume 89, Issue 18, Articles (18xxxx)

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Appl. Phys. Lett. 89, 181101 (2006); http://dx.doi.org/10.1063/1.2372737 (3 pages)

Z. D. Gao, S. N. Zhu, Shih-Yu Tu, and A. H. Kung
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Catalytic activity of enzymes immobilized on AlGaN/GaN solution gate field-effect transistors

B. Baur, J. Howgate, H.-G. von Ribbeck, Y. Gawlina, V. Bandalo, G. Steinhoff, M. Stutzmann, and M. Eickhoff

Appl. Phys. Lett. 89, 183901 (2006); http://dx.doi.org/10.1063/1.2369534 (3 pages) | Cited 21 times

Online Publication Date: 30 October 2006

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Enzyme-modified field-effect transistors (EnFETs) were prepared by immobilization of penicillinase on AlGaN/GaN solution gate field-effect transistors. The influence of the immobilization process on enzyme functionality was analyzed by comparing covalent immobilization and physisorption. Covalent immobilization by Schiff base formation on GaN surfaces modified with an aminopropyltriethoxysilane monolayer exhibits high reproducibility with respect to the enzyme/substrate affinity. Reductive amination of the Schiff base bonds to secondary amines significantly increases the stability of the enzyme layer. Electronic characterization of the EnFET response to penicillin G indicates that covalent immobilization leads to the formation of an enzyme (sub)monolayer.
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87.80.-y Biophysical techniques (research methods)
87.15.R- Reactions and kinetics
87.14.E- Proteins
85.30.Tv Field effect devices

Increased cell response to zirconia ceramics by surface modification

Jingxian Zhang, Dongliang Jiang, Noriko Kotobuki, Masahiko Maeda, Motohiro Hirose, Hajime Ohgushi, and Mikio Iwasa

Appl. Phys. Lett. 89, 183902 (2006); http://dx.doi.org/10.1063/1.2385208 (3 pages) | Cited 5 times

Online Publication Date: 3 November 2006

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The authors present a method to enhance the cell response to zirconia materials without sacrificing the mechanical properties. Zirconia specimens prepared by slip casting and pressureless sintering have excellent mechanical properties. After hydrothermal treatment in phosphoric solutions at 150 °C for 2 h, enhanced cell proliferation and high alkaline phosphatase activity were determined. This can be explained by the development of a more biocompatible surface phase (zirconium phosphate), which is believed to have high affinity for proteins. Results showed that it was possible to increase the cell response to zirconia ceramics by the proposed surface modification method.
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87.85.J- Biomaterials
87.17.-d Cell processes
87.14.E- Proteins
81.65.-b Surface treatments
81.20.Ev Powder processing: powder metallurgy, compaction, sintering, mechanical alloying, and granulation
81.40.Gh Other heat and thermomechanical treatments
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