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3 Jul 2006

Volume 89, Issue 1, Articles (01xxxx)

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Appl. Phys. Lett. 89, 011901 (2006); http://dx.doi.org/10.1063/1.2218670 (3 pages)

L. S. Wang, S. Tripathy, B. Z. Wang, J. H. Teng, S. Y. Chow, and S. J. Chua
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Single cell recordings with pairs of complementary transistors

Sven Meyburg, Günter Wrobel, Regina Stockmann, Jürgen Moers, Sven Ingebrandt, and Andreas Offenhäusser

Appl. Phys. Lett. 89, 013901 (2006); http://dx.doi.org/10.1063/1.2219339 (3 pages) | Cited 8 times

Online Publication Date: 6 July 2006

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Floating gate field-effect transistors (FETs) for the detection of extracellular signals from electrogenic cells were fabricated in a complementary metal oxide semiconductor process. Additional passivation layers protected the transistor gates from the electrolyte solution. To compare the signals from n- and p-FETs, two electronically separated, but locally adjacent transistors were combined to one measuring unit. The paired sensing area of this unit had the dimension of a single cell. Simultaneous recordings with n- and p-channel floating gate FETs from a single cell exhibited comparable amplitudes and identical time courses. The experiments indicate that both types of FETs express similar sensitivities.
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87.80.-y Biophysical techniques (research methods)
87.19.R- Mechanical and electrical properties of tissues and organs
87.17.-d Cell processes
85.30.Tv Field effect devices
81.65.Rv Passivation
07.07.Df Sensors (chemical, optical, electrical, movement, gas, etc.); remote sensing

Resonant photoemission study of single-strand deoxyribonucleic acid

Li Wang, Ke-Qin Zhang, Xingyu Gao, Xiang-Yang Liu, and Andrew T. S. Wee

Appl. Phys. Lett. 89, 013902 (2006); http://dx.doi.org/10.1063/1.2219427 (3 pages) | Cited 3 times

Online Publication Date: 6 July 2006

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The electronic structure of single-strand DNA was studied by resonant photoemission spectroscopy at C 1s and N 1s resonances to understand the charge transfer process in DNA. The intensity enhancements of valence electrons were clearly observed at both C 1s and N 1s resonances although they emerged at different regions of the valence band at each resonance. These observations provide direct evidence for the localized nature of the unoccupied states in the nucleobases and backbone, and support the validity of the charge hopping model in long-range charge migration in DNA.
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87.15.M- Spectra of biomolecules
87.14.G- Nucleic acids
34.70.+e Charge transfer

Correlating thalamocortical connectivity and activity

Luciano da Fontoura Costa and Olaf Sporns

Appl. Phys. Lett. 89, 013903 (2006); http://dx.doi.org/10.1063/1.2219736 (3 pages) | Cited 5 times

Online Publication Date: 7 July 2006

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The segregated regions of the mammalian cerebral cortex and thalamus form an extensive and complex network, whose structure and function are still only incompletely understood. The present letter describes an application of the concepts of complex networks and random walks that allows the identification of nonrandom, highly structured features of thalamocortical connections and their potential effects on dynamic interactions between cortical areas in the cat brain. Utilizing large-scale anatomical data sets of this thalamocortical system, we investigate uniform random walks in such a network by considering the steady state eigenvector of the respective stochastic matrix. It is shown that thalamocortical connections are organized in such a way as to guarantee strong correlation between the outdegree and occupancy rate (a stochastic measure potentially related to activation) of each cortical area. Possible organizational principles underlying this effect are identified and discussed.
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87.19.L- Neuroscience
89.75.-k Complex systems
02.50.Ey Stochastic processes
05.40.Fb Random walks and Levy flights
02.10.Ud Linear algebra
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Optically trapped aqueous droplets for single molecule studies

J. E. Reiner, A. M. Crawford, R. B. Kishore, Lori S. Goldner, K. Helmerson, and M. K. Gilson

Appl. Phys. Lett. 89, 013904 (2006); http://dx.doi.org/10.1063/1.2219977 (3 pages) | Cited 10 times

Online Publication Date: 7 July 2006

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We demonstrate a technique for creating, manipulating, and combining femtoliter volume chemical containers. The containers are surfactant-stabilized aqueous droplets in a low index-of-refraction fluorocarbon medium. The index-of-refraction mismatch between the container and fluorocarbon is such that individual droplets can be optically trapped by single focus laser beams, i.e., optical tweezers. Here, we trap and manipulate individual droplets, detect the fluorescence from single dye and red fluorescent protein molecules encapsulated in droplets, and observe fluorescence resonance energy transfer from a single dye pair on a deoxyribonucleic acid molecule encapsulated in a droplet.
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87.80.Cc Optical trapping
87.14.E- Proteins
87.14.G- Nucleic acids
87.15.M- Spectra of biomolecules
37.10.Mn Slowing and cooling of molecules
37.10.Pq Trapping of molecules
33.50.Dq Fluorescence and phosphorescence spectra
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