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28 Aug 2006

Volume 89, Issue 9, Articles (09xxxx)

Issue Cover Spotlight Figure

Appl. Phys. Lett. 89, 093101 (2006); http://dx.doi.org/10.1063/1.2338808 (3 pages)

Nicholas Jabari Lee, Rajiv K. Kalia, Aiichiro Nakano, and Priya Vashishta
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Optical generation of high frequency ultrasound using two-dimensional gold nanostructure

Yang Hou, Jin-Sung Kim, Shai Ashkenazi, Matthew O’Donnell, and L. Jay Guo

Appl. Phys. Lett. 89, 093901 (2006); http://dx.doi.org/10.1063/1.2344929 (3 pages) | Cited 8 times

Online Publication Date: 31 August 2006

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A two-dimensional (2D) gold nanostructure is used to optically generate high frequency ultrasound. The structure consists of 2D arrangements of gold nanoparticles, sandwiched between a transparent substrate and a 4.5 μm thick polydimethylsiloxane (PDMS) layer. The acoustic signal displays significant improvements compared to a bulk black PDMS films (the current state of the art) at frequencies from 50 to 100 MHz. The high optical extinction ratio of the gold nanostructure provides a convenient method to construct an integrated transmit/receive optoacoustic array. These results show that a 2D gold nanostructure can be used to produce high frequency arrays for ultrasound imaging.
Show PACS
87.63.D- Ultrasonography
87.85.Qr Nanotechnologies-design
87.85.Rs Nanotechnologies-applications
43.80.Qf
43.80.Vj
42.79.Jq Acousto-optical devices
43.35.Ud

Buried microfluidic channel for integrated patch-clamping assay

Wee-Liat Ong, Jack-Sheng Kee, Agarwal Ajay, Nagarajan Ranganathan, Kum-Cheong Tang, and Levent Yobas

Appl. Phys. Lett. 89, 093902 (2006); http://dx.doi.org/10.1063/1.2336213 (3 pages) | Cited 11 times

Online Publication Date: 1 September 2006

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The authors present a microfluidic device towards an integrated patch-clamping assay. The device replaces conventional glass patch pipette with a buried microfluidic channel on silicon substrate. The microchannel fabrication involves reforming doped glass under heat and pressure, a process, in principle, analogous to the heat-pulling/polishing of glass patch pipettes. Unlike etching substrate, this process leaves a smooth glass surface for seal formation with cell membrane. The microchannel is evolved from a trapped void inside the trench during nonconformal deposition of the doped glass. The results of seal formation with mammalian cells captured at such microchannel opening are presented.
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87.80.Jg Patch clamping and other physiological measurements
85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices
47.85.Np Fluidics
87.16.D- Membranes, bilayers, and vesicles
87.16.Uv Active transport processes
81.15.Gh Chemical vapor deposition (including plasma-enhanced CVD, MOCVD, ALD, etc.)
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