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19 Mar 2007

Volume 90, Issue 12, Articles (12xxxx)

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Appl. Phys. Lett. 90, 123101 (2007); http://dx.doi.org/10.1063/1.2716242 (3 pages)

G. Z. Shen, Y. Bando, J. Q. Hu, and D. Golberg
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Observation of protein-protein interaction by dielectric relaxation spectroscopy of protein solutions for biosensor application

Brian A. Mazzeo and Andrew J. Flewitt

Appl. Phys. Lett. 90, 123901 (2007); http://dx.doi.org/10.1063/1.2716350 (3 pages) | Cited 6 times

Online Publication Date: 21 March 2007

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Dielectric spectroscopy was used to measure the dielectric relaxation of bovine serum albumin, Protein A, and rabbit IgG in solution. Measurements were performed with an impedance analyzer and dielectric cell. Protein additions to bulk solution were measured by differential dielectric relaxation spectroscopy, presented as a method to measure the individual contributions of proteins to relaxation phenomena and reduce effects of electrode polarization. Relaxation characteristics of the proteins individually and as a complex were observed. Frequency shifts in the relaxation characteristics indicate binding. This illustrates the potential use of bulk solution dielectric relaxation as the principle of operation for a biosensor.
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87.15.N- Properties of solutions of macromolecules
87.80.-y Biophysical techniques (research methods)
87.14.E- Proteins

Acoustic Rayleigh scattering at individual micron-sized bubbles

V. Sboros, S. D. Pye, T. A. Anderson, C. M. Moran, and W. N. McDicken

Appl. Phys. Lett. 90, 123902 (2007); http://dx.doi.org/10.1063/1.2714996 (3 pages) | Cited 9 times

Online Publication Date: 22 March 2007

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A microacoustic system based on a wide-bandwidth commercial piezoelectric transducer is presented in this letter. The system allows objective measurement of nonlinear Rayleigh scatter from single microbubbles. Two different types of microbubbles were exposed to a range of ultrasonic frequencies and amplitudes. Statistical examination of their scatter provides an understanding of their dissolution/destruction behavior and an insight on inertial cavitation. These high sensitivity measurements are key to the understanding of nonlinear scatter, may be employed to devise new signal processing techniques for imaging and better microbubble engineering.
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87.63.D- Ultrasonography
43.80.Qf Medical diagnosis with acoustics
43.80.Vj Acoustical medical instrumentation and measurement techniques
47.55.dp Cavitation and boiling
43.38.Fx Piezoelectric and ferroelectric transducers
02.50.-r Probability theory, stochastic processes, and statistics
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